Potential of natural polysaccharide for ovarian cancer therapy

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2024-11-04 DOI:10.1016/j.carbpol.2024.122946

Miaomiao Xiao , Siwen Chen , Yaochen Yang , Ke Hu , Yantao Song , Zhipeng Hou , Siyu Sun , Liqun Yang

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引用次数: 0

Abstract

Ovarian cancer, characterized by high lethality, presents a significant clinical challenge. The standard first-line treatment is surgery and chemotherapy; however, postoperative chemotherapy is often ineffective and associated with severe side effects and the development of drug resistance. Consequently, there is an urgent need for innovative drug delivery strategies to enhance therapeutic efficacy. Natural polysaccharide polymers with high bioactivity have been extensively investigated for use alone or as adjuvants to chemotherapy and radiotherapy, and also for the preparation of efficient delivery systems for ovarian cancer therapy. This paper aims to review recent advances in the application of natural polysaccharides, including hyaluronic acid, chitosan, alginate, and cellulose, in the therapy of ovarian cancer. This paper primarily discusses the anti-tumor properties inherent to these natural polysaccharide polymers and offers a summary of their role in delivery systems used in ovarian cancer therapy.

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天然多糖治疗卵巢癌的潜力

卵巢癌具有致死率高的特点，是一项重大的临床挑战。标准的一线治疗方法是手术和化疗；然而，术后化疗往往效果不佳，并伴有严重的副作用和耐药性的产生。因此，迫切需要创新的给药策略来提高疗效。具有高生物活性的天然多糖聚合物已被广泛研究，用于单独使用或作为化疗和放疗的辅助剂，以及制备卵巢癌治疗的高效给药系统。本文旨在综述透明质酸、壳聚糖、海藻酸和纤维素等天然多糖在卵巢癌治疗中的最新应用进展。本文主要讨论了这些天然多糖聚合物固有的抗肿瘤特性，并总结了它们在卵巢癌治疗中使用的给药系统中的作用。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.