Hepcidin: A potent antimicrobial peptide involved in iron homeostasis

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2024-11-13 DOI:10.1016/j.genrep.2024.102082

Saiedeh Razi Soofiyani , Elghar Soltani , Masoomeh Kashef Nejad-Khelejani , Reza Ghanbari , Mohammad Yousef Memar

引用次数: 0

Abstract

Antimicrobial peptides (AMPs) are involved in the innate immunity of human body to battle microbial pathogens. In addition, human AMPs play also an important role in several biological procedures included cell proliferation, soft tissue damage healing and control of immune response. Hepcidin is a cysteine-rich 25-amino acid AMP produced by the liver and plays an important role in the control of iron homeostasis in the human body. Furthermore, its principal role in iron regulation, hepcidin is also an AMP with wide-spectrum antimicrobial effects on Gram-positive bacteria, Gram-negative bacteria, and fungi without triggering side effects in mammalian cells. Significantly, the bactericidal properties of hepcidin are dependent on the integrity of the disulfide bridges and precise folding of hepcidin. The aims of present study were review the biological effects specially role in iron homeostasis and antimicrobial effects of hepcidin.

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肝素一种参与铁平衡的强效抗菌肽

抗菌肽（AMPs）参与了人体对抗微生物病原体的先天免疫。此外，人体抗菌肽还在细胞增殖、软组织损伤愈合和控制免疫反应等多个生物过程中发挥重要作用。肝素是一种由肝脏产生的富含半胱氨酸的 25- 氨基酸 AMP，在控制人体铁平衡方面发挥着重要作用。除了在铁调节方面的主要作用外，肝素还是一种对革兰氏阳性菌、革兰氏阴性菌和真菌具有广谱抗菌作用的 AMP，不会对哺乳动物细胞产生副作用。值得注意的是，血球素的杀菌特性取决于二硫桥的完整性和血球素的精确折叠。本研究的目的是回顾血红素的生物效应，特别是在铁平衡和抗菌方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.