George Jiao, Daniel Zhu, Jeffrey L Shakin, Albert S Li
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引用次数: 0
Abstract
Purpose: To describe a case of endophthalmitis caused by Haemophilus influenzae, an encapsulated bacterium, after intravitreal (IVT) injection of pegcetacoplan. Methods: A single retrospective case was evaluated. Results: An 88-year-old woman with a history of diabetes mellitus, on dialysis for chronic kidney disease, hypertension, hypothyroidism, diffuse large B-cell lymphoma, and geographic atrophy in both eyes received an IVT injection of pegcetacoplan in both eyes. She subsequently developed endophthalmitis in the right eye caused by H influenzae. Further bloodwork showed Proteus mirabilis bacteremia. Conclusions: Pegcetacoplan, a complement inhibitor, may be associated with intraocular infections with encapsulated organisms, especially in immunocompromised patients.
目的：描述一例在玻璃体内注射培加氯普兰（IVT）后由流感嗜血杆菌（一种包裹细菌）引起的眼内炎病例。方法：对一例回顾性病例进行评估。结果一名 88 岁的妇女，患有糖尿病、慢性肾病透析、高血压、甲状腺功能减退症、弥漫性大 B 细胞淋巴瘤，双眼均有地理性萎缩。随后，她的右眼出现了由流感嗜血杆菌引起的眼内炎。进一步的血液检查显示她患上了奇异变形杆菌菌血症。结论培加氯普兰是一种补体抑制剂，可能会导致眼内感染包裹体，尤其是免疫力低下的患者。
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