Impact of non-sugar sweeteners on metabolism beyond sweet taste perception.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-11-16 DOI:10.1016/j.tem.2024.10.008

Herbert Herzog, Lei Zhang, Luigi Fontana, G Gregory Neely

引用次数: 0

Abstract

Non-sugar sweeteners (NSS), low- or no-calorie alternatives to sugar, are marketed for weight loss and improved blood glucose control in people with diabetes. However, their health effects remain controversial. This review provides a brief overview of sweet taste perception and summarizes experimental findings of the impact of NSS on cardiometabolic health in animal models and humans. We also review evidence suggesting that many NSS are not metabolically inert, highlighting the challenges in related human studies. Given the conflicting and unclear data on health outcomes, additional mechanistic studies, particularly in animal models, are necessary to clarify how NSS influence feeding behaviors and energy homoeostasis.

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非糖甜味剂对新陈代谢的影响超出了对甜味的感知。

非糖甜味剂（NSS）是糖的低热量或无热量替代品，在市场上被用来减肥和改善糖尿病患者的血糖控制。然而，它们对健康的影响仍存在争议。本综述简要概述了甜味的感知，并总结了在动物模型和人体中 NSS 对心脏代谢健康影响的实验结果。我们还回顾了表明许多 NSS 并非代谢惰性的证据，强调了相关人体研究中的挑战。鉴于有关健康结果的数据相互矛盾且不明确，有必要进行更多的机理研究，特别是在动物模型中进行研究，以阐明非钠盐如何影响进食行为和能量平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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