Investigating psychiatric morbidity, hopelessness and suicide risk in patients with 22q11.2 deletion syndrome: a case-control study.

IF 2.9 4区医学 Q2 PSYCHIATRY

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-11-18 DOI:10.1080/13651501.2024.2427624

Isabella Berardelli, Mariarosaria Cifrodelli, Salvatore Sarubbi, Carlotta Giuliani, Giulia Antonelli, Fabrizio Schirripa, Carolina Putotto, Federica Pulvirenti, Marco Innamorati, Maurizio Pompili

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引用次数: 0

Abstract

Background: The psychiatric phenotype of the 22q11.2 deletion syndrome (22q11DS) has been largely described.

Objectives: With a case-control study design, we now compared a sample of 22q11DS patients with a psychiatric diagnosis with a sample of psychiatric patients without 22q11DS to investigate possible differences between groups for depression severity, hopelessness, and suicide. Patients with 22q11DS were divided into two groups according to the levels of hopelessness to evaluate the relationship between hopelessness and the severity of the 22q11DS, the level of disability, functional impairment, physical frailty, and autonomy level.

Results: Results showed that suicide risk evaluated with the C-SSRS was similar in the two groups of patients and that a diagnosis of 22q11DS does not appear to be a risk factor for suicide; however, 22q11DS patients had more severe hopelessness. Patients with a more severe clinical presentation and worse overall functioning have higher levels of depressive symptoms and hopelessness.

Conclusions: The results suggest the need to assess and monitor psychiatric symptoms in patients with 22q11DS.

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调查 22q11.2 缺失综合征患者的精神病发病率、绝望感和自杀风险：一项病例对照研究。

背景：22q11.2缺失综合征（22q11DS）的精神表型已被广泛描述：目前，我们采用病例对照研究设计，将被诊断为精神病的 22q11DS 患者样本与未被诊断为 22q11DS 的精神病患者样本进行比较，以研究两组患者在抑郁严重程度、无望感和自杀方面可能存在的差异。根据无望程度将 22q11DS 患者分为两组，以评估无望程度与 22q11DS 严重程度、残疾程度、功能障碍、身体虚弱程度和自主程度之间的关系：结果显示，两组患者使用 C-SSRS 评估的自杀风险相似，22q11DS 诊断似乎不是自杀的风险因素；但是，22q11DS 患者的绝望感更为严重。临床表现更严重、整体功能更差的患者抑郁症状和绝望程度更高：结果表明，有必要对 22q11DS 患者的精神症状进行评估和监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Clinical Practice 医学-精神病学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry. The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice. Focus on the practical aspects of managing and treating patients. Essential reading for the busy psychiatrist, trainee and interested physician. Includes original research papers, comprehensive review articles and short communications. Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.