Adenovirus 41 diversity in Arizona (USA) using wastewater-based epidemiology, long-range PCR, and pathogen sequencing between October 2019 and March 2020.

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Epidemiology and Infection Pub Date : 2024-11-18 DOI:10.1017/S095026882400133X

Temitope O C Faleye, Peter Skidmore, Amir Elyaderani, Sangeet Adhikari, Nicole Kaiser, Abriana Smith, Allan Yanez, Tyler Perleberg, Erin M Driver, Rolf U Halden, Arvind Varsani, Matthew Scotch

引用次数: 0

Abstract

By coupling long-range polymerase chain reaction, wastewater-based epidemiology, and pathogen sequencing, we show that adenovirus type 41 hexon-sequence lineages, described in children with hepatitis of unknown origin in the United States in 2021, were already circulating within the country in 2019. We also observed other lineages in the wastewater, whose complete genomes have yet to be documented from clinical samples.

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在 2019 年 10 月至 2020 年 3 月期间，利用基于废水的流行病学、长程 PCR 和病原体测序，研究亚利桑那州（美国）腺病毒 41 的多样性。

通过将长程聚合酶链式反应、基于废水的流行病学和病原体测序结合起来，我们发现 2021 年在美国不明原因肝炎患儿中发现的 41 型腺病毒六元序列，在 2019 年已经在美国国内流行。我们还观察到废水中的其他品系，它们的完整基因组尚未从临床样本中得到记录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epidemiology and Infection 医学-传染病学

CiteScore

4.10

自引率

2.40%

发文量

366

审稿时长

3-6 weeks

期刊介绍： Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.