Unlocking the promise of MANF in diseases: Mechanistic insights and therapeutic potentials.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Reports Pub Date : 2024-11-16 DOI:10.1007/s11033-024-10111-9

Lingling Yuan, Qiqiao Dai, Xirui Wang, Jing Yang, Bin Yuan

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Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a ubiquitous neurotrophic factor that exhibits a variety of physiological functions and plays a critical role in the exploitation of therapeutic potential across a range of diseases, including cardiovascular disorders, nervous system diseases, metabolic imbalances, and cancers. In the context of cardiac diseases, MANF significantly promotes cardiomyocyte survival and improves cardiac functionality. Furthermore, MANF not only provides neuroprotection by shielding neurons from damage and promoting nerve regeneration in neurological disorders, but also involves in insulin resistance, lipid metabolism disturbances and fat-containing liver lesions. However, the oncogenic or tumor suppressive function of MANF in cancer remains unclear, requiring further investigation to elucidate its precise role in the process of cancer initiation and progression. This review aims to summarize the latest advancements in understanding the molecular pathways, intricate mechanisms, and therapeutic potential of MANF in the prevention and treatment of various diseases, emphasizing its multifaceted contributions to health and disease management.

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揭开 MANF 在疾病中的应用前景：机理认识和治疗潜力。

间脑星形胶质细胞源性神经营养因子（MANF）是一种无处不在的神经营养因子，具有多种生理功能，在开发心血管疾病、神经系统疾病、代谢失衡和癌症等一系列疾病的治疗潜力方面发挥着至关重要的作用。在心脏疾病方面，曼月乐能显著促进心肌细胞存活并改善心脏功能。此外，在神经系统疾病中，MANF 不仅能保护神经元免受损伤并促进神经再生，还能参与胰岛素抵抗、脂质代谢紊乱和含脂肪的肝脏病变。然而，MANF在癌症中的致癌或抑癌功能仍不明确，需要进一步研究以阐明其在癌症发生和发展过程中的确切作用。本综述旨在总结 MANF 在预防和治疗各种疾病的分子途径、复杂机制和治疗潜力方面的最新进展，强调 MANF 对健康和疾病管理的多方面贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.