Causal effect of breast cancer on endometrial cancer risk: A two-sample Mendelian randomization study

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2024-11-10 DOI:10.1016/j.ejogrb.2024.11.013

Meng Wang , Lan Li , Jing Li , Yongwei Li , Zhuoli Wang , Yuan Guo , Guochao Mao

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Abstract

Background

Observational studies have indicated a higher incidence of endometrial cancer in individuals with breast cancer. However, to date, there is a dearth of Mendelian randomization (MR) studies that explore the causal relationship between breast cancer and the risk of endometrial cancer.

Material and methods

We conducted MR to investigate the causal relationship between breast cancer and endometrial cancer risk in European populations.

Results

A total of 112 valid instrumental variables (IVs) were included in the analysis. Our research has revealed a compelling causal association between genetic predisposition for breast cancer and an augmented likelihood of developing endometrial cancer (Inverse variance weighted (IVW) method, odds ratio (OR) = 1.105, 95 % confidence interval (CI): 1.025 to 1.181, p = 0.003; Weighted median method, OR = 1.109, 95 % CI: 1.020 to 1.205, p = 0.015; Weighted mode method, OR = 1.101, 95 % CI: 1.013 to 1.195, p = 0.025).

Conclusion

To our knowledge, this study is the first to report a causal association between breast cancer and endometrial cancer risk. Robust results were obtained through rigorous testing for heterogeneity and pleiotropy. Our findings indicate a causal effect of breast cancer on the risk of endometrial cancer.

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乳腺癌对子宫内膜癌风险的因果效应：双样本孟德尔随机研究。

背景：观察性研究表明，乳腺癌患者的子宫内膜癌发病率较高。然而，迄今为止，探讨乳腺癌与子宫内膜癌风险之间因果关系的孟德尔随机化（MR）研究还很缺乏：我们进行了孟德尔随机化研究，以调查欧洲人群中乳腺癌与子宫内膜癌风险之间的因果关系：结果：共有 112 个有效的工具变量（IV）被纳入分析。我们的研究揭示了乳腺癌遗传易感性与子宫内膜癌发病几率增加之间令人信服的因果关系（逆方差加权（IVW）法，几率比（OR）= 1.105, 95 % 置信区间 (CI): 1.025 to 1.181, p = 0.003; 加权中位数法，OR = 1.109, 95 % CI: 1.020 to 1.205, p = 0.015; 加权模式法，OR = 1.101, 95 % CI: 1.013 to 1.195, p = 0.025）：据我们所知，该研究首次报告了乳腺癌与子宫内膜癌风险之间的因果关系。通过对异质性和多义性的严格测试，得出了可靠的结果。我们的研究结果表明，乳腺癌对子宫内膜癌风险有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.