{"title":"Catalyst Free, Microwave-assisted Synthesis of Benzylidene Schiff Bases and Evaluation of Their Biological Properties","authors":"Betokali K. Zhimomi, Khonzani Yanthan, Manthae Phom, Phitovili Achumi, Putusenla Imchen, Shokip Tumtin, Tovishe Phucho","doi":"10.1002/slct.202404710","DOIUrl":null,"url":null,"abstract":"<p>Phenol Schiff bases can conveniently be prepared in high yield by the reaction of the appropriate aminophenols and aldehydes in solventless condition. The final target compounds were characterized by FT-IR, <sup>1</sup>HNMR, <sup>13</sup>CNMR, and Mass spectroscopy. Microwave assistance reduced the reaction time and solvent, increased the yield, purity, and eased the work up. The compounds were found to possess moderate to good antibacterial activity implying that the synthesized compounds may make excellent candidates for further studies aimed at discovering novel antibacterial agents. In vitro antioxidant qualities of the synthesized Schiff bases are also evaluated. In the tests for reducing power and radical scavenging, all the compounds demonstrated strong antioxidant activity even surpassing that of the positive control, Trolox.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 43","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistrySelect","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/slct.202404710","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Phenol Schiff bases can conveniently be prepared in high yield by the reaction of the appropriate aminophenols and aldehydes in solventless condition. The final target compounds were characterized by FT-IR, 1HNMR, 13CNMR, and Mass spectroscopy. Microwave assistance reduced the reaction time and solvent, increased the yield, purity, and eased the work up. The compounds were found to possess moderate to good antibacterial activity implying that the synthesized compounds may make excellent candidates for further studies aimed at discovering novel antibacterial agents. In vitro antioxidant qualities of the synthesized Schiff bases are also evaluated. In the tests for reducing power and radical scavenging, all the compounds demonstrated strong antioxidant activity even surpassing that of the positive control, Trolox.
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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