Expanding the Therapeutic Horizons of Psilocybin in Mental Health

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2024-10-15 DOI:10.1021/acsmedchemlett.4c0048810.1021/acsmedchemlett.4c00488

Robert B. Kargbo*,

引用次数: 0

Abstract

Psilocybin, a naturally occurring psychedelic compound, has recently emerged as a promising therapeutic agent for mental health. This Patent Highlight explores the innovative approaches to harnessing psilocybin’s potential across various contexts. These include clinical trials targeting severe psychiatric conditions, the integration of low-dose psilocybin into dietary products to promote general mental well-being, and the personalization of psilocybin dosing for optimal treatment of depression and anxiety. These advancements demonstrate psilocybin’s versatility and potential to reshape conventional mental health treatment paradigms, mainly through personalized medicine and accessible wellness applications.

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拓展迷幻药在精神健康领域的治疗范围

迷幻药是一种天然迷幻化合物，最近已成为一种很有前景的精神健康治疗剂。本专利摘要探讨了在各种情况下利用迷幻药潜力的创新方法。其中包括针对严重精神疾病的临床试验、将低剂量迷幻药融入饮食产品以促进一般精神健康，以及迷幻药剂量的个性化以优化抑郁症和焦虑症的治疗。这些进展证明了迷幻药的多功能性和重塑传统精神健康治疗模式的潜力，主要是通过个性化医疗和无障碍健康应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.