TFEB links the cGAS-STING pathway to lysosome biogenesis.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-11-14 DOI:10.1016/j.tcb.2024.10.011

Yaping Meng, Xinran Li, Haoxing Xu

引用次数: 0

Abstract

The cGAS-STING pathway senses the level of double-stranded (ds)DNA in the cytosol, and is required for innate immunity through its effector, TBK1. A recent study by Lv et al. reports that STING activation also simultaneously promotes lysosomal biogenesis by inducing nuclear translocation of the transcription factors TFEB/TFE3 independent of TBK1.

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TFEB 将 cGAS-STING 通路与溶酶体生物生成联系起来。

cGAS-STING 通路可感知细胞膜中双链 DNA 的水平，并通过其效应因子 TBK1 实现先天性免疫。Lv 等人最近的一项研究报告指出，STING 的激活还能通过诱导独立于 TBK1 的转录因子 TFEB/TFE3 的核转位，同时促进溶酶体的生物生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.