The impact of sleep restriction on cerebrovascular reactivity and cognitive outcomes in healthy adolescents: A pilot crossover trial

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2024-11-09 DOI:10.1016/j.sleep.2024.11.005

Amy Chan , Chun Ting Au , Myrtha E. Reyna , Amanda Robertson , Kirstin Walker , Robyn Westmacott , Manohar Shroff , Luc Mertens , Nomazulu Dlamini , Indra Narang

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引用次数: 0

Abstract

Background

The underlying mechanism for the association between sleep restriction (SR) and unfavorable cognitive outcomes in children and adolescents remains unclear. This study aimed to understand the effect of 5-night experimental SR on magnetic resonance imaging (MRI) measurements of cerebrovascular reactivity (CVR) and cognitive function in adolescents.

Methods

This randomized crossover study compared two sleep conditions, SR and Control Sleep (CS) in a home setting. Healthy adolescents aged 15–18 years were recruited. The protocol began with two nights of baseline sleep to record participants’ habitual sleep duration, followed by the two sleep conditions in the randomly allocated sequence, either SR (6 h in bed for 5 nights) followed by CS (9 h in bed for 5 nights), or the reverse sequence. Their sleep-wake pattern was monitored by an accelerometer and a sleep diary throughout the study period. Cerebral hemodynamics were assessed by hypercapnic challenge blood oxygen level-dependent (BOLD) MRI of CVR. Cognitive function was evaluated by NIH Toolbox Cognitive Battery on the day immediately after each sleep condition.

Results

A total of 27 participants (8 males; mean age: 16.8 ± 0.7 years, range 15–18 years) were included in the study. The average sleep duration was significantly reduced in the SR condition compared to the CS condition (320 ± 34 min vs. 426 ± 45 min, p < 0.001). The CVR in the temporal occipital fusiform cortex [adjusted β(95 % CI) = −0.091(-0.010 to −0.172), p = 0.032] and occipital lobe [adjusted β(95 % CI) = −0.087 (−0.002 to −0.172), p = 0.045] was significantly lower following the SR condition when compared to the CS condition. Participants also had lower performance scores in the inhibitory control [adjusted β(95 % CI) = −6.0(−0.9 to −11.0), p = 0.019] and cognitive flexibility [adjusted β(95 % CI) = −6.6 (−1.7 to −11.6), p = 0.008] domains after the SR condition when compared to the CS condition.

Conclusions

Short-term SR is associated with poorer cognitive function possibly through reduced cerebral vasodilatory capacity in specific cognitive regions.

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限制睡眠对健康青少年脑血管反应性和认知结果的影响：交叉试验

背景：睡眠限制（SR）与儿童和青少年不利的认知结果之间的内在机制仍不清楚。本研究旨在了解 5 晚实验性睡眠限制对青少年脑血管反应性（CVR）和认知功能磁共振成像（MRI）测量的影响：这项随机交叉研究比较了家庭环境中的两种睡眠条件：SR 和对照睡眠（CS）。研究招募了 15-18 岁的健康青少年。首先进行两晚的基线睡眠，记录参与者的习惯睡眠时间，然后按照随机分配的顺序进行两种睡眠条件的对比，SR（连续 5 晚在床上睡 6 小时）和 CS（连续 5 晚在床上睡 9 小时）或相反的顺序。在整个研究期间，他们的睡眠-觉醒模式由加速度计和睡眠日记进行监测。通过高碳酸血症挑战血氧水平依赖性（BOLD）核磁共振成像评估脑血流动力学。认知功能在每次睡眠条件结束后的第二天通过 NIH 工具箱认知电池进行评估：共有 27 名参与者（8 名男性；平均年龄：16.8 ± 0.7 岁，15-18 岁不等）参与了研究。与 CS 条件相比，SR 条件下的平均睡眠时间明显缩短（320 ± 34 分钟 vs. 426 ± 45 分钟，p 结论：短期 SR 与睡眠质量较差有关：短期SR与认知功能较差有关，这可能是由于特定认知区域的脑血管舒张能力降低所致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.