The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson's disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2024-11-15 DOI:10.1007/s10072-024-07878-x

Fengjuan Jiao, Lincong Zhou, Zaixin Wu

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引用次数: 0

Abstract

Backgrounds: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor symptoms and non-motor symptoms. It has been found that intestinal issues usually precede motor symptoms. Microorganisms in the gastrointestinal tract can affect central nervous system through the microbiota-gut-brain axis. Accumulating evidence has shown that disturbances in the microbiota-gut-brain axis are linked with PD. Thus, this pathway appears to be a promising therapeutic target for treatment of PD.

Objectives: In this review, we mainly described gut dysbiosis in PD and their underlying mechanisms for mediating neuroinflammation and peripheral immune response in PD pathology and futher discussed the potential small-molecule compounds and genic therapeutic strategies targeting the microbiota-gut-brain axis and their applications in PD.

Conclusions: Studies have found that some small molecule compounds and alterations of inflammation-related genes can improve the motor and non-motor symptoms of PD by improving the microbiota-gut-brain axis, which may provide potentially beneficial drugs and molecular targets for the therapies of PD.

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微生物群-肠-脑轴：帕金森病小分子化合物和基因治疗策略的潜在靶点。

背景：帕金森病（PD）是一种常见的神经退行性疾病，以运动症状和非运动症状为特征。研究发现，肠道问题通常先于运动症状出现。胃肠道中的微生物可通过微生物群-肠-脑轴影响中枢神经系统。越来越多的证据表明，微生物群-肠-脑轴的紊乱与帕金森病有关。因此，这一途径似乎是治疗帕金森病的一个有希望的治疗靶点：在这篇综述中，我们主要描述了帕金森病中的肠道菌群失调及其在帕金森病病理中介导神经炎症和外周免疫反应的潜在机制，并进一步讨论了针对微生物群-肠-脑轴的潜在小分子化合物和基因治疗策略及其在帕金森病中的应用：研究发现，一些小分子化合物和炎症相关基因的改变可以通过改善微生物群-肠-脑轴来改善帕金森病的运动和非运动症状，这可能为帕金森病的治疗提供潜在的有益药物和分子靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.