Spectrum-effect relationship between HPLC fingerprints and antioxidant activities of Bletilla striata

IF 2.8 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Chromatography B Pub Date : 2024-11-01 DOI:10.1016/j.jchromb.2024.124351

Sha Wen, Yuzhi Luo, Lingyi Liu, Lili Zhou, Lingli Li, Siqi Wang, Huixin Song, Songyuan Xia, Weifeng Li, Xiaofeng Niu

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Abstract

Bletilla striata is a perennial herb that was first published in Shennong’s Classic of the Materia Medica, pharmacological studies have shown that it has the activities of promoting wound healing, anti-inflammatory and antioxidant. However, the relationship between the antioxidant activity and the chemical composition of Bletilla striata is still unclear. In this paper, the chemometric method was used to construct the spectral effect relationship between the fingerprints of 20 batches of Bletilla striata extracts from different origins and their in vitro antioxidant activities. The results showed that the chemical composition of the samples from different sources varied significantly, while the samples from Shaanxi and Hubei provinces were of relatively better quality. Among the 10 common peaks, coelonin, gymnoside IX and dactylorhin A were considered to be significantly correlated with the antioxidant activity of Bletilla striata. The results of this study will provide a basis and further insights for the quality evaluation and quality control of Bletilla striata.

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高效液相色谱指纹图谱与白芨抗氧化活性之间的谱效关系

白芨是一种多年生草本植物，最早见于《神农本草经》，药理研究表明它具有促进伤口愈合、抗炎和抗氧化的活性。然而，抗氧化活性与白芨化学成分之间的关系尚不明确。本文采用化学计量学方法构建了20批次不同产地的条叶紫苏提取物指纹图谱与其体外抗氧化活性之间的谱效关系。结果表明，不同产地样品的化学成分差异较大，陕西省和湖北省的样品质量相对较好。在 10 个常见峰值中，认为薏苡仁苷、钩藤苷 IX 和麦冬皂苷 A 与条纹叶紫苏的抗氧化活性显著相关。本研究的结果将为条斑紫苏的质量评价和质量控制提供依据和进一步的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chromatography B 医学-分析化学

CiteScore

5.60

自引率

3.30%

发文量

306

审稿时长

44 days

期刊介绍： The Journal of Chromatography B publishes papers on developments in separation science relevant to biology and biomedical research including both fundamental advances and applications. Analytical techniques which may be considered include the various facets of chromatography, electrophoresis and related methods, affinity and immunoaffinity-based methodologies, hyphenated and other multi-dimensional techniques, and microanalytical approaches. The journal also considers articles reporting developments in sample preparation, detection techniques including mass spectrometry, and data handling and analysis. Developments related to preparative separations for the isolation and purification of components of biological systems may be published, including chromatographic and electrophoretic methods, affinity separations, field flow fractionation and other preparative approaches. Applications to the analysis of biological systems and samples will be considered when the analytical science contains a significant element of novelty, e.g. a new approach to the separation of a compound, novel combination of analytical techniques, or significantly improved analytical performance.