Intermediate cells with activated JAK/STAT signaling in prostate regeneration and diseases

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-11-15 DOI:10.1038/s41588-024-01977-3

引用次数: 0

Abstract

NKX3.1-expressing intermediate Basal-B cells represent a transient basal stem cell state during prostate regeneration, inflammation and cancer initiation. Remarkably, activation of JAK/STAT signaling is essential in regulating expansion and differentiation of Basal-B-like cells during prostate inflammation, identifying this signaling pathway as a potential therapeutic target in prostatitis associated with increased Basal-B signature.

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在前列腺再生和疾病中激活 JAK/STAT 信号的中间细胞

NKX3.1表达的中间Basal-B细胞代表了前列腺再生、炎症和癌症诱发过程中的一种短暂的基础干细胞状态。值得注意的是，在前列腺炎症过程中，JAK/STAT 信号的激活对调节 Basal-B 样细胞的扩增和分化至关重要，这就确定了这一信号通路是与 Basal-B 特征增加相关的前列腺炎的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution