A Multifaceted Exploration of Status Asthmaticus: A Retrospective Analysis in a Romanian Hospital.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of Clinical Medicine Pub Date : 2024-11-04 DOI:10.3390/jcm13216615

Adriana Ana Trusculescu, Versavia Maria Ancusa, Camelia Corina Pescaru, Norbert Wellmann, Corneluta Fira-Mladinescu, Cristian Iulian Oancea, Ovidiu Fira-Mladinescu

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Abstract

Background: Status asthmaticus is a severe, life-threatening asthma exacerbation requiring urgent medical intervention. This study aims to examine its epidemiology in Timis County, Romania, over 11 years. Methods: A retrospective analysis was conducted using hospital records from 2013 to 2023, focusing on demographic, geospatial, and temporal distributions. Network analysis of the recorded comorbidities was used to identify phenotypic clusters among patients. Results: Females and older adults were disproportionately affected. Several triggers and geospatial patterns were identified. Five phenotypic clusters were determined: two in the T2-high endotype, two in T2-low, and a mixed one. Conclusions: The findings highlight the need for personalized asthma management strategies and public healthcare interventions in Timiș County, addressing specific demographic and geospatial factors. This study also provides a valuable reference for similar regions.

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对哮喘状态的多方面探索：罗马尼亚一家医院的回顾性分析。

背景：哮喘状态是一种严重的、危及生命的哮喘恶化，需要紧急医疗干预。本研究旨在调查罗马尼亚蒂米斯县 11 年来的哮喘流行病学。研究方法使用 2013 年至 2023 年的医院记录进行回顾性分析，重点关注人口、地理空间和时间分布。对记录的合并症进行网络分析，以确定患者的表型集群。结果显示女性和老年人受到的影响尤为严重。确定了几种诱发因素和地理空间模式。确定了五个表型集群：两个为 T2 高内型，两个为 T2 低内型，一个为混合型。结论：研究结果突出表明，提米什县需要针对特定的人口和地理空间因素制定个性化的哮喘管理策略和公共医疗干预措施。这项研究也为类似地区提供了有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.70

自引率

7.70%

发文量

6468

审稿时长

16.32 days

期刊介绍： Journal of Clinical Medicine (ISSN 2077-0383), is an international scientific open access journal, providing a platform for advances in health care/clinical practices, the study of direct observation of patients and general medical research. This multi-disciplinary journal is aimed at a wide audience of medical researchers and healthcare professionals. Unique features of this journal: manuscripts regarding original research and ideas will be particularly welcomed.JCM also accepts reviews, communications, and short notes. There is no limit to publication length: our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.