Functionalities of pH-responsive DNA nanostructures in tumor-targeted strategies

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Liyue Wen and Min Wang
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引用次数: 0

Abstract

Nanostructures integrating pH-sensitive DNA motifs have emerged as versatile platforms for active tumor targeting, owing to their ability to undergo conformation changes in response to the common acidic environment of the tumor extracellular matrix and endocytosis pathway. This review summarizes the latest advances in the design and application of various pH-responsive DNA nanostructures for tumor-targeted strategies, including tumor recognition, cell imaging, dynamic nanocarrier construction, and controlled drug release. A comprehensive framework for pH-controlled multi-stage tumor targeting is introduced, addressing the divergences in targeting strategies for extracellular and intracellular environments. The unique attributes, practical performance and application challenges of pH-responsive DNA nanostructures are also critically discussed to provide guidance for future development in this field.

Abstract Image

pH 响应 DNA 纳米结构在肿瘤靶向策略中的功能。
整合了 pH 敏感 DNA 主题的纳米结构由于能够在肿瘤细胞外基质和内吞途径的常见酸性环境中发生构象变化,已成为肿瘤靶向的多功能平台。本综述总结了各种 pH 响应 DNA 纳米结构设计和应用于肿瘤靶向策略的最新进展,包括肿瘤识别、细胞成像、动态纳米载体构建和药物控释。针对细胞外和细胞内环境中靶向策略的差异,介绍了 pH 控制多阶段肿瘤靶向的综合框架。此外,还批判性地讨论了 pH 响应 DNA 纳米结构的独特属性、实际性能和应用挑战,为该领域的未来发展提供指导。
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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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