Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-10 DOI:10.1016/j.arr.2024.102577

Ying-ying Gu , Xin-ru Zhao , Nan Zhang , Yuan Yang , Ying Yi , Qian-hang Shao , Ming-xuan Liu , Xiao-ling Zhang

引用次数: 0

Abstract

Neurodegenerative diseases, as common diseases in the elderly, tend to become younger due to environmental changes, social development and other factors. They are mainly characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system, and common diseases include Parkinson's disease, Alzheimer's disease, Huntington's disease and so on. Mitochondria are important organelles for adenosine triphosphate (ATP) production in the brain. In recent years, a large amount of evidence has shown that mitochondrial dysfunction plays a direct role in neurodegenerative diseases, which is expected to provide new ideas for the treatment of related diseases. This review will summarize the main mechanisms of mitochondrial dysfunction in neurodegenerative diseases, as well as collating recent advances in the study of mitochondrial disorders and new therapies.

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将线粒体功能障碍作为神经退行性疾病的治疗策略：当前见解与未来方向。

神经退行性疾病作为老年人的常见病，受环境变化、社会发展等因素的影响，有年轻化的趋势。主要表现为中枢或周围神经系统神经元进行性丢失或功能障碍，常见疾病包括帕金森病、阿尔茨海默病、亨廷顿病等。线粒体是大脑产生三磷酸腺苷（ATP）的重要细胞器。近年来，大量证据表明线粒体功能障碍在神经退行性疾病中起着直接作用，有望为相关疾病的治疗提供新思路。本综述将总结神经退行性疾病中线粒体功能障碍的主要机制，并整理线粒体疾病研究的最新进展和新疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.