Celludinone C, a new dihydroisobenzofuran isolated from Talaromyces cellulolyticus BF-0307.

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-11-14 DOI:10.1038/s41429-024-00785-5

Reiko Seki, Kenichiro Nagai, Keisuke Kobayashi, Satoru Shigeno, Tatsuya Shirahata, Yoshinori Kobayashi, Taichi Ohshiro, Hiroshi Tomoda

引用次数: 0

Abstract

Celludinones A and B, isolated from the fungus Talaromyces cellulolyticus BF-0307, were inhibitors of sterol O-acyltransferase (SOAT). Further searches for their congeners in the culture broth of the fungus by LC/UV and LC/MS analysis resulted in the discovery of four structurally related compounds, including a new dihydroisobenzofuran named celludinone C (1). The structure of 1, including its absolute stereochemistry, was elucidated by 1D/2D NMR and electronic circular dichroism (ECD) spectra. All of these compounds inhibited both SOAT1 and 2, with IC₅₀ values ranging from 8.5 to 30 µM.

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Celludinone C，一种从纤维素溶解塔拉酵母菌 BF-0307 中分离出来的新型二氢异苯并呋喃。

从真菌 Talaromyces cellulolyticus BF-0307 中分离出的 Celludinones A 和 B 是甾醇 O-酰基转移酶（SOAT）的抑制剂。通过 LC/UV 和 LC/MS 分析，进一步在该真菌的培养液中寻找它们的同系物，结果发现了四种结构相关的化合物，其中包括一种名为 Celludinone C（1）的新的二氢异苯并呋喃。通过一维/二维核磁共振和电子圆二色性（ECD）光谱，阐明了 1 的结构，包括其绝对立体化学结构。所有这些化合物都能抑制 SOAT1 和 2，其 IC50 值介于 8.5 至 30 µM 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.