The future of hypertension pharmacotherapy: Ongoing and future clinical trials for hypertension

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-11-08 DOI:10.1016/j.cpcardiol.2024.102922

Taha Mansoor MD , Fatima Farrukh MD , Subaina N. Khalid MD , Dmitry Abramov MD , Erin D. Michos MD, MHS , Anurag Mehta MD , Timir K. Paul MD, PhD , Sourbha S. Dani MD, MSc , Mahmoud Al Rifai MD , Arunima Misra MD , Vijay Nambi MD, PhD , Salim S. Virani MD, PhD , Abdul Mannan Khan Minhas MD, MS

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引用次数: 0

Abstract

Hypertension is among the most prevalent diagnoses across the world and increases the risk of many serious health problems, such as stroke, heart disease, and kidney disease. Pharmacological approaches to treat hypertension are often required and reduce blood pressure through mechanisms such as vasodilation, inhibition of the renin-angiotensin-aldosterone pathway, and increased urine output to reduce blood volume, among other mechanisms. Further research is ongoing to find novel pathways and mechanisms to treat hypertension, which we summarize in this review. We used clinicaltrials.gov to gather information about ongoing clinical trials of pharmacological hypertension therapy as of March 2024 and found 103 clinical trials that met our criteria. The interventions of these 103 clinical trials include novel and previously approved pharmacological and dietary supplement therapies for hypertension. We aim to use these clinical trials to provide insight into the future therapies and practices of hypertension treatment.

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高血压药物治疗的未来：正在进行的和未来的高血压临床试验。

高血压是全球最常见的疾病之一，会增加许多严重健康问题的风险，如中风、心脏病和肾病。高血压通常需要药物治疗，通过血管扩张、抑制肾素-血管紧张素-醛固酮途径、增加尿量以减少血容量等机制来降低血压。我们在本综述中总结了目前正在进行的进一步研究，以寻找治疗高血压的新途径和新机制。我们使用 clinicaltrials.gov 收集了截至 2024 年 3 月正在进行的高血压药物治疗临床试验信息，发现有 103 项临床试验符合我们的标准。这 103 项临床试验的干预措施包括治疗高血压的新型和以前批准的药物疗法和膳食补充疗法。我们希望通过这些临床试验来深入了解高血压治疗的未来疗法和实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.