Leisure-time physical activity, cardiorespiratory fitness, and cognitive decline in middle-aged and older adults - The ELSA-Brasil study

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2024-11-09 DOI:10.1016/j.puhe.2024.11.008

Natan Feter , Danilo de Paula , Rodrigo Citton P. dos Reis , David A. Raichlen , Sandhi Maria Barreto , Claudia Kimie Suemoto , Maria Inês Schmidt , Bruce B. Duncan

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引用次数: 0

Abstract

Objectives

Dementia is a fast-growing public health problem. This study examined the association of physical activity and estimated cardiorespiratory fitness (eCRF) with the risk of cognitive impairment.

Study design

Multicentric, prospective cohort study.

Methods

We analyzed 10,121 participants of the ELSA-Brasil study. We assessed leisure-time physical activity using the long version of the IPAQ questionnaire and defined moderate-to-vigorous physical activity (MVPA) per week. We applied a non-exercise prediction equation to estimate eCRF and classified participants as unfit (lowest tertile) and fit. Leisure-time MVPA and eCRF were measured at baseline and follow-up. Incident cognitive impairment was based on memory, language, and executive function assessed at baseline and follow-up.

Results

During a median of 8.1 (7.8–8.5) years of follow-up, we identified 396 (3.9 %) incident cases of cognitive impairment. There was an inverse, non-linear association between the incidence of cognitive impairment and both leisure time MVPA and eCRF. Low eCRF (IRR: 1.29; 95%CI: 1.02, 1.64) and low MVPA (IRR: 1.40; 1.09, 1.82) were independently associated with an increased incidence. Increasing 1 MET in eCRF from baseline to follow-up visit was associated with a lower incidence of cognitive impairment (IRR: 0.80; 95%CI: 0.71, 0.91), while a decrease of 13.7 min per day in leisure time MVPA is associated with an increased incidence (IRR: 1.16; 95%CI: 1.01, 1.33) of cognitive impairment. These associations remained statistically significant in adults under 65 but not in older adults.

Conclusion

Low eCRF and leisure time MVPA are strong and independent predictors of incident cognitive impairment especially in middle-aged adults.

查看原文本刊更多论文

中老年人的闲暇体育活动、心肺功能和认知能力下降--ELSA-巴西研究。

目标：痴呆症是一个快速增长的公共健康问题。本研究探讨了体育锻炼和估计心肺功能（eCRF）与认知障碍风险之间的关系：多中心、前瞻性队列研究：我们对 ELSA-Brasil 研究的 10,121 名参与者进行了分析。我们使用长版 IPAQ 问卷对闲暇时间的体力活动进行了评估，并定义了每周中等强度到高强度的体力活动（MVPA）。我们采用非运动预测方程来估算 eCRF，并将参与者分为不适合（最低三分位数）和适合。我们在基线和随访时测量了闲暇时的 MVPA 和 eCRF。根据基线和随访时评估的记忆、语言和执行功能，得出认知障碍的发生率：在中位数为 8.1（7.8-8.5）年的随访期间，我们发现了 396 例（3.9%）认知障碍病例。认知障碍的发生率与闲暇时间 MVPA 和 eCRF 之间存在非线性反比关系。低 eCRF（IRR：1.29；95%CI：1.02，1.64）和低 MVPA（IRR：1.40；1.09，1.82）与发病率增加有独立关联。从基线到随访期间，eCRF 增加 1 MET 与认知障碍发生率降低有关（IRR：0.80；95%CI：0.71，0.91），而每天闲暇时间 MVPA 减少 13.7 分钟与认知障碍发生率增加有关（IRR：1.16；95%CI：1.01，1.33）。这些关联在 65 岁以下的成年人中仍具有统计学意义，但在老年人中则没有：结论：低 eCRF 和闲暇时间 MVPA 是认知障碍事件的强有力的独立预测因素，尤其是在中年人中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.