Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013-2023.

IF 2.7 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Risk Management and Healthcare Policy Pub Date : 2024-11-09 eCollection Date: 2024-01-01 DOI:10.2147/RMHP.S487340

Jiangtao Yu, Benfeng Zheng, Na Liu, Yiheng Zhu, Fen Hui, Jin Zhang, Lin Luan

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引用次数: 0

Abstract

Objective: To investigate the epidemiology, and hospitalization of tetanus in Suzhou, Jiangsu Province, China, focusing on the severity of the disease, treatment, outcomes and hospitalization costs, and to explore the risk factors for severe tetanus.

Methods: This retrospective, multicenter observational study analyzed tetanus patients admitted to various medical institutions between 2013 and 2023. Patients were classified into two groups as severe or non-severe, using the Ablett classification. Differences between the two groups were compared using the Chi-squared test, Fisher's exact test and Mann-Whitney U-test. Binary logistic regression analysis was used to evaluate potential risk factors for severe disease.

Results: A total of 63 patients with tetanus were included in this study. The median age of the patients was 57.0 (48.0-74.0) years, with a predominance of males (65.1%). There was an overall increasing trend in the rate of severe illness in tetanus patients from 2013-2023 (P<0.001). The proportion of patients admitted to the hospital was highest (39.7%) in summer (June-August) (P=0.001). The rate of severe tetanus was significantly higher in patients aged ≥65 years than in those aged 0-40 years and 41-64 years (P=0.019). The incubation period was 8.0(5.0-11.0) days for severe tetanus patients and 11.0 (8.0-18.0) days for non-severe patients (P=0.005). Compared to the non-severe group, the severe group shouldered a higher hospitalization cost, with total costs amounting to US $19062.8(4675.4-29,385.4) and US $4291.1(1356.6-19,635.4), respectively. Binary logistic regression analysis revealed that patients aged 65 years and above significantly increased the risk of developing severe disease (OR = 3.345, 95% CI: 1.039-10.770).

Conclusion: Tetanus occurs primarily in the summer in Suzhou City, Jiangsu Province, China. The incubation period is shorter in patients with severe tetanus. The elderly are the main affected population, with the risk of developing severe disease escalating with advancing age. Knowledge of tetanus immunoprophylaxis should be strengthened to further reduce morbidity and mortality.

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2013-2023 年苏州市破伤风病例的趋势和住院治疗结果：2013-2023年苏州市多中心回顾性研究》。

目的调查中国江苏省苏州市破伤风的流行病学和住院情况，重点关注疾病的严重程度、治疗、结果和住院费用，并探讨重症破伤风的风险因素：这项多中心回顾性观察研究分析了2013年至2023年期间各医疗机构收治的破伤风患者。根据阿伯利特分类法，患者被分为重症和非重症两组。两组之间的差异采用卡方检验、费雪精确检验和曼-惠特尼U检验进行比较。二元逻辑回归分析用于评估重症的潜在风险因素：本研究共纳入 63 名破伤风患者。患者的中位年龄为 57.0（48.0-74.0）岁，男性占多数（65.1%）。2013-2023 年间，破伤风患者的重症率总体呈上升趋势（PP=0.001）。年龄≥65岁患者的重症破伤风发病率明显高于0-40岁和41-64岁的患者（P=0.019）。重症破伤风患者的潜伏期为 8.0（5.0-11.0）天，非重症患者为 11.0（8.0-18.0）天（P=0.005）。与非重症组相比，重症组的住院费用更高，总费用分别为 19062.8 美元（4675.4-29385.4）和 4291.1 美元（1356.6-19635.4）。二元逻辑回归分析显示，65 岁及以上的患者患重症的风险明显增加（OR = 3.345，95% CI：1.039-10.770）：结论：破伤风主要发生在中国江苏省苏州市的夏季。严重破伤风患者的潜伏期较短。老年人是主要患病人群，随着年龄的增长，患重症的风险也在增加。应加强破伤风免疫预防知识的普及，以进一步降低发病率和死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Risk Management and Healthcare Policy Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.20

自引率

2.90%

发文量

242

审稿时长

16 weeks

期刊介绍： Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include: Public and community health Policy and law Preventative and predictive healthcare Risk and hazard management Epidemiology, detection and screening Lifestyle and diet modification Vaccination and disease transmission/modification programs Health and safety and occupational health Healthcare services provision Health literacy and education Advertising and promotion of health issues Health economic evaluations and resource management Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.