Global burden associated with rare infectious diseases of poverty in 2021: findings from the Global Burden of Disease Study 2021.

IF 8.1 1区医学

Infectious Diseases of Poverty Pub Date : 2024-11-13 DOI:10.1186/s40249-024-01249-6

Yujia Bao, Yongxuan Li, Yibin Zhou, Ne Qiang, Tianyun Li, Yuzheng Zhang, Marc K C Chong, Shi Zhao, Xiaobei Deng, Xiaoxi Zhang, Lefei Han, Jinjun Ran

{"title":"Global burden associated with rare infectious diseases of poverty in 2021: findings from the Global Burden of Disease Study 2021.","authors":"Yujia Bao, Yongxuan Li, Yibin Zhou, Ne Qiang, Tianyun Li, Yuzheng Zhang, Marc K C Chong, Shi Zhao, Xiaobei Deng, Xiaoxi Zhang, Lefei Han, Jinjun Ran","doi":"10.1186/s40249-024-01249-6","DOIUrl":null,"url":null,"abstract":"Background: Rare infectious diseases of poverty (rIDPs) involve more than hundreds of tropical diseases, which dominantly affect people living in impoverished and marginalized regions and fail to be prioritized in the global health agenda. The neglect of rIDPs could impede the progress toward sustainable development. This study aimed to estimate the disease burden of rIDPs in 2021, which would be pivotal for setting intervention priorities and mobilizing resources globally.Methods: Leveraging data from the Global Burden of Disease Study 2021, the study reported both numbers and age-standardized rates of prevalence, mortality, disability-adjusted life-years (DALYs), years lived with disability, and years of life lost of rIDPs with corresponding 95% uncertainty intervals (UIs) at global, regional, and national levels. The temporal trends between 1990 and 2021 were assessed by the joinpoint regression analysis. A Bayesian age-period-cohort model was used to project the disease burden for 2050.Results: In 2021, there were 103.76 million (95% UI: 102.13, 105.44 million) global population suffered from rIDPs with an age-standardized DALY rate of 58.44 per 100,000 population (95% UI: 42.92, 77.26 per 100,000 population). From 1990 to 2021, the age-standardized DALY rates showed an average annual percentage change of - 0.16% (95% confidence interval: - 0.22, - 0.11%). Higher age-standardized DALY rates were dominated in sub-Saharan Africa (126.35 per 100,000 population, 95% UI: 91.04, 161.73 per 100,000 population), South Asia (80.80 per 100,000 population, 95% UI: 57.31, 114.10 per 100,000 population), and countries with a low socio-demographic index. There was age heterogeneity in the DALY rates of rIDPs, with the population aged under 15 years being the most predominant. Females aged 15-49 years had four-times higher age-standardized DALY rates of rIDPs than males in the same age. The projections indicated a slight reduction in the disease burden of rIDPs by 2050.Conclusions: There has been a slight reduction in the disease burden of rIDPs over the past three decades. Given that rIDPs mainly affect populations in impoverished regions, targeted health strategies and resource allocation are in great demand for these populations to further control rIDPs and end poverty in all its forms everywhere.","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"13 1","pages":"85"},"PeriodicalIF":8.1000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558835/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious Diseases of Poverty","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40249-024-01249-6","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Rare infectious diseases of poverty (rIDPs) involve more than hundreds of tropical diseases, which dominantly affect people living in impoverished and marginalized regions and fail to be prioritized in the global health agenda. The neglect of rIDPs could impede the progress toward sustainable development. This study aimed to estimate the disease burden of rIDPs in 2021, which would be pivotal for setting intervention priorities and mobilizing resources globally.

Methods: Leveraging data from the Global Burden of Disease Study 2021, the study reported both numbers and age-standardized rates of prevalence, mortality, disability-adjusted life-years (DALYs), years lived with disability, and years of life lost of rIDPs with corresponding 95% uncertainty intervals (UIs) at global, regional, and national levels. The temporal trends between 1990 and 2021 were assessed by the joinpoint regression analysis. A Bayesian age-period-cohort model was used to project the disease burden for 2050.

Results: In 2021, there were 103.76 million (95% UI: 102.13, 105.44 million) global population suffered from rIDPs with an age-standardized DALY rate of 58.44 per 100,000 population (95% UI: 42.92, 77.26 per 100,000 population). From 1990 to 2021, the age-standardized DALY rates showed an average annual percentage change of - 0.16% (95% confidence interval: - 0.22, - 0.11%). Higher age-standardized DALY rates were dominated in sub-Saharan Africa (126.35 per 100,000 population, 95% UI: 91.04, 161.73 per 100,000 population), South Asia (80.80 per 100,000 population, 95% UI: 57.31, 114.10 per 100,000 population), and countries with a low socio-demographic index. There was age heterogeneity in the DALY rates of rIDPs, with the population aged under 15 years being the most predominant. Females aged 15-49 years had four-times higher age-standardized DALY rates of rIDPs than males in the same age. The projections indicated a slight reduction in the disease burden of rIDPs by 2050.

Conclusions: There has been a slight reduction in the disease burden of rIDPs over the past three decades. Given that rIDPs mainly affect populations in impoverished regions, targeted health strategies and resource allocation are in great demand for these populations to further control rIDPs and end poverty in all its forms everywhere.

查看原文本刊更多论文

2021 年与罕见贫困传染病有关的全球负担：2021 年全球疾病负担研究的结果。

背景：罕见贫困传染病（rIDPs）涉及数百种热带疾病，主要影响生活在贫困和边缘化地区的人们，在全球健康议程中没有被列为优先事项。对贫困疾病的忽视可能会阻碍可持续发展的进程。本研究旨在估算2021年rIDPs的疾病负担，这对于确定干预重点和在全球范围内调动资源至关重要：方法：本研究利用《2021 年全球疾病负担研究》的数据，报告了全球、地区和国家层面上 rIDPs 的患病率、死亡率、残疾调整生命年 (DALYs)、残疾生存年数和生命损失年数的数量和年龄标准化比率，以及相应的 95% 不确定区间 (UIs)。接合点回归分析评估了 1990 年至 2021 年间的时间趋势。采用贝叶斯年龄-时期-队列模型预测 2050 年的疾病负担：结果：2021 年，全球有 1.0376 亿（95% UI：1.0213 亿，1.0544 亿）人罹患 rIDPs，年龄标准化 DALY 率为每 10 万人 58.44（95% UI：每 10 万人 42.92，77.26）。从 1990 年到 2021 年，年龄标准化 DALY 率的年均百分比变化为 -0.16%（95% 置信区间：-0.22，-0.11%）。撒哈拉以南非洲（每 10 万人 126.35 例，95% 置信区间：每 10 万人 91.04 例，161.73 例）、南亚（每 10 万人 80.80 例，95% 置信区间：每 10 万人 57.31 例，114.10 例）和社会人口指数较低的国家的年龄标准化残疾调整寿命年率较高。急性呼吸系统综合症的残疾调整寿命年数率存在年龄差异，其中以 15 岁以下人群居多。15-49 岁女性的 rIDP 年龄标准化残疾调整寿命率是同龄男性的四倍。预测显示，到 2050 年，rIDPs 的疾病负担将略有减轻：结论：在过去三十年中，rIDPs 的疾病负担略有减少。鉴于 rIDPs 主要影响贫困地区的人口，这些地区的人口亟需有针对性的卫生战略和资源分配，以进一步控制 rIDPs，消除各地各种形式的贫困。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Infectious Diseases of Poverty INFECTIOUS DISEASES-

自引率

1.20%

发文量

368

期刊介绍： Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.