Assessment of Serum FABP-4 Levels in Hypothyroidism Patients: A Comparative Analysis With a Control Group and Their Correlation With Liver Function Tests and Biochemical Factors

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Endocrinology, Diabetes and Metabolism Pub Date : 2024-11-11 DOI:10.1002/edm2.70011

Mundher Mohammad Hamzeh Aldulaimi, Afsaneh Shafiei, Somayeh Ghorbani, Fatima Mohammadzadeh, Safoura Khajeniazi

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Abstract

Background

The association of serum FABP4 and other biochemical-related parameters is important to determine complications of hypothyroidism. This study aimed to evaluate serum FABP-4 levels in hypothyroidism patients in comparison with a control group.

Materials and Methods

Forty-five patients with hypothyroidism and 45 healthy volunteers were included in this study. Liver function tests, thyroid hormones panel, lipid profile and serum FABP-4 levels were measured and compared in both groups, and their correlations were analysed.

Results

Serum FABP-4 levels were significantly higher in patients with hypothyroidism compared to the control group (p = 0.002), and serum FABP-4 level in males was higher than it in females (p = 0.022). There was a significant difference between patients with hypothyroidism and the control group in the levels of AST (p = 0.012). Moreover, serum FABP-4 levels were negatively correlated with age (p = 0.016) and positively correlated with weight (p = 0.044).

Conclusion

In our study, there was a notable increase in serum FABP-4 concentration among hypothyroidism subjects. The data suggest that FABP-4 could potentially be a superior diagnostic indicator for hypothyroidism when contrasted with a control cohort in future studies.

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甲状腺功能减退症患者血清 FABP-4 水平的评估：与对照组的比较分析及其与肝功能检验和生化因素的相关性

背景：血清 FABP4 与其他生化相关参数的关联对于确定甲减并发症非常重要。本研究旨在评估甲减患者与对照组的血清 FABP-4 水平：本研究纳入了 45 名甲减患者和 45 名健康志愿者。测量并比较两组患者的肝功能检测、甲状腺激素检测、血脂谱和血清 FABP-4 水平，并分析其相关性：结果：与对照组相比，甲状腺功能减退症患者的血清FABP-4水平明显升高（P = 0.002），男性血清FABP-4水平高于女性（P = 0.022）。甲状腺功能减退症患者的谷草转氨酶水平与对照组有明显差异（p = 0.012）。此外，血清 FABP-4 水平与年龄呈负相关（p = 0.016），与体重呈正相关（p = 0.044）：结论：在我们的研究中，甲状腺功能减退症患者的血清 FABP-4 浓度明显升高。这些数据表明，在未来的研究中，如果与对照组进行对比，FABP-4 有可能成为甲状腺功能减退症的一个较好的诊断指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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