Application of botulinum toxin A in tissue repair and regeneration

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2024-11-13 DOI:10.1016/j.toxicon.2024.108172

Xuan-Zhu Guo , Ya-Nan Niu , Xuan Zhou , Qiao Wei , Meng Li , Jia-Ning Xia , Yu-Qi Cui , Chao-Xin Chai , Yi-Ming Wang , Li-Ping Chen

引用次数: 0

Abstract

Tissue repair and regeneration present significant clinical challenges. Despite the array of treatments currently available in this domain, the urgent demand for innovative therapies persists, with the goal of enhancing patient quality of life. Recently, the application of botulinum neurotoxin type A (BoNT/A) has expanded within the realm of tissue repair and regeneration. This review critically examines the utilization of BoNT/A, specifically focusing on its vascular effects, potential in nerve regeneration, and contributions to bone healing. This analysis not only offers fresh insights into the diverse mechanisms of action of BoNT/A but also explores additional therapeutic possibilities for patients.

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肉毒杆菌毒素 A 在组织修复和再生中的应用。

组织修复和再生是一项重大的临床挑战。尽管目前在这一领域已有一系列治疗方法，但对创新疗法的迫切需求依然存在，目的是提高患者的生活质量。最近，A 型肉毒杆菌神经毒素（BoNT/A）在组织修复和再生领域的应用不断扩大。这篇综述对 BoNT/A 的应用进行了批判性研究，特别关注其血管效应、神经再生潜力以及对骨愈合的贡献。这一分析不仅对 BoNT/A 的各种作用机制提供了新的见解，还为患者探索了更多治疗的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.