REM sleep behavior disorder: Relation between aggressiveness and emotions expressed in dream enactment and cognitive and anxiety/depression status

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2024-11-08 DOI:10.1016/j.sleep.2024.11.008

Paulo Bugalho , Marta Magriço , Vítor Mendes Ferreira

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引用次数: 0

Abstract

Aggressiveness and negative emotions in dreams reports of patients with alfa-synucleinopathies have been associated with cognitive dysfunction. Observation of dream enactment episodes could be a more precise method to capture dream content in patients with REM sleep behavior disorder (RBD). Our objective was to assess the relation between aggressive and emotional dream enactment episodes in patients with RBD and cognition and depression/anxiety.

Motor events (ME) during REM sleep were classified by visual inspection of video-PSG files. Cognition and anxiety/depression were assessed with MoCA and the Hospital Anxiety and Depression Scale (HADS), respectively. Multivariate regression analysis was performed, with MoCA or HADS scores as predictors, age and DED as co-variates and aggressive, negative and positive ME frequency (raw values, per total and per complex indexes) as the dependent variable.

We included 15 patients with isolated RBD and 12 and 4 with RBD associated with Parkinson's disease and Dementia with Lewy Bodies, respectively. They presented a total of 873 ME. There was a significant positive association between HADS score and violent/complex and negative emotion/complex indexes. There was a significant positive association between MoCA score and violent/complex index.

A significant correlation between depression/anxiety severity and negative emotion and aggression ME frequency agrees with the dream continuity hypothesis and suggests that REM sleep acts as a regulator of emotional experience. Patients with a higher prevalence of aggressive ME had higher scores in cognitive testing, suggesting that the elaboration of these complex movements could depend on the integrity of cognitive functions.

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快速眼动睡眠行为障碍：梦境中表现出的攻击性和情绪与认知和焦虑/抑郁状态之间的关系。

α-突触核蛋白病患者梦境中的攻击性和负面情绪与认知功能障碍有关。观察梦境发作可能是捕捉快速眼动睡眠行为障碍（RBD）患者梦境内容的一种更精确的方法。我们的目的是评估 RBD 患者的攻击性和情绪性梦境发作与认知和抑郁/焦虑之间的关系。通过目视检查视频-PSG 文件，对快速眼动睡眠期间的运动事件 (ME) 进行分类。认知和焦虑/抑郁分别通过MoCA和医院焦虑抑郁量表（HADS）进行评估。我们进行了多变量回归分析，将 MoCA 或 HADS 评分作为预测因子，年龄和 DED 作为共变量，攻击性、阴性和阳性 ME 频率（原始值、每项总指数和每项复合指数）作为因变量。我们纳入了 15 名孤立的 RBD 患者，以及分别与帕金森病和路易体痴呆相关的 12 名和 4 名 RBD 患者。他们共出现了 873 次 ME。HADS评分与暴力/复杂和负性情绪/复杂指数之间存在明显的正相关。MoCA评分与暴力/复杂指数呈显著正相关。抑郁/焦虑严重程度与负性情绪和攻击性ME频率之间存在明显的相关性，这与梦境连续性假说一致，并表明快速眼动睡眠是情绪体验的调节器。攻击性ME发生率较高的患者在认知测试中得分较高，这表明这些复杂动作的精细化可能取决于认知功能的完整性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.