Daytime napping and depressive symptoms in bipolar disorder: A cross-sectional analysis of the APPLE cohort

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2024-11-09 DOI:10.1016/j.sleep.2024.11.006

Yuichi Esaki , Kenji Obayashi , Keigo Saeki , Kiyoshi Fujita , Nakao Iwata , Tsuyoshi Kitajima

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Abstract

Background

The relationship between daytime napping and depression remains debatable. Thus, we investigated whether daytime napping is associated with depressive symptoms in patients with bipolar disorder.

Methods

In a cross-sectional study, we enrolled 204 outpatients with bipolar disorder who were participants in the Association between Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study. Each participant's daytime napping was measured using an actigraph over 7 consecutive days. Depressive symptoms were evaluated using the Montgomery–Åsberg Depression Rating Scale, and scores of ≥8 points were considered indicative of a depressed state.

Results

One-hundred and ten (53.9 %) participants were depressed. In multivariable logistic regression analysis, as the number of nap days, number of naps per day, and nap duration increased, the odds ratio (OR) for depressed state significantly increased. Additionally, compared to the participants who did not nap, the participants who napped on five or more days a week or who had an average nap duration over 60 min had more than three times higher ORs in the depressed state (number of nap days: OR, 3.66; 95 % confidence interval [CI], 1.32–10.17; nap duration: OR, 3.14; 95 % CI, 1.12–8.81).

Conclusions

We found a significant and independent association between daytime napping and depressive symptoms in patients with bipolar disorder. Further studies are warranted to identify the effect of short napping on depressive symptoms in patients with bipolar disorder.

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躁郁症患者白天小睡与抑郁症状：APPLE队列的横断面分析。

背景白天小睡与抑郁症之间的关系仍存在争议。因此，我们研究了白天小睡是否与双相情感障碍患者的抑郁症状有关：在一项横断面研究中，我们招募了 204 名双相情感障碍门诊患者，他们都是双相情感障碍病理与日常生活中光暴露之间的关联（APPLE）队列研究的参与者。研究人员连续 7 天使用行动计测量了每位患者的日间小睡情况。抑郁症状采用蒙哥马利-奥斯伯格抑郁评分量表进行评估，得分≥8分被视为抑郁状态：结果：110 人（53.9%）患有抑郁症。在多变量逻辑回归分析中，随着午睡天数、每天午睡次数和午睡持续时间的增加，抑郁状态的几率比（OR）显著增加。此外，与不午睡的参与者相比，每周午睡五天或五天以上或平均午睡时间超过 60 分钟的参与者抑郁状态的 OR 值高出三倍多（午睡天数：OR，3.66；95 % 置信区间 [CI]，1.32-10.17；午睡时间：结论：我们发现，双相情感障碍患者的日间小睡与抑郁症状之间存在明显的独立关联。有必要开展进一步研究，以确定短时小睡对双相情感障碍患者抑郁症状的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.