Rare co-occurrence of probable pernicious anemia and autoimmune hepatitis in a 55-year-old male patient: A case report.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

SAGE Open Medical Case Reports Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.1177/2050313X241290382

Ahmed Ibrahim Siddiqui, Muhammad Luqman, Ahmed Mustafa Siddiqui, Arqam Bin Aijaz, Muhammad Abdul Wasay Zuberi, Sameer Abdul Rauf, Hussain Haider Shah

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Abstract

This is a case of probable pernicious anemia in the setting of autoimmune hepatitis. A 55-year-old male patient presented to the Emergency Room at Dr. Ruth K.M. Pfau Civil Hospital, Karachi with complaints of diarrhea and fever and was subsequently transferred to the medicine ward. The patient also had signs of unexplained anemia. We performed laboratory tests and were able to rule out the common causes of liver pathology, including viral hepatitis. For blood, the values showed decreased hemoglobin levels and an elevated Mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV) (114 fL), indicating macrocytosis. Finally, we were able to conclude autoimmune pathology after the results of antibody testing demonstrated positive lab values for anti-smooth muscle antibodies, antinuclear antibodies, and anti-gastric parietal cell antibodies. The patient had developed pernicious anemia in the setting of autoimmune hepatitis, which is an extremely rare case and documented instances are scarce in the available literature regarding such cases.

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一名 55 岁男性患者罕见地同时患有恶性贫血和自身免疫性肝炎：病例报告。

这是一例自身免疫性肝炎引起的恶性贫血病例。一名 55 岁的男性患者因腹泻和发烧来到卡拉奇露丝-K.M.-普福医生平民医院急诊室就诊，随后被转到内科病房。患者还伴有不明原因的贫血症状。我们对其进行了化验检查，排除了包括病毒性肝炎在内的肝脏病变的常见病因。血液数值显示血红蛋白水平下降，平均血红蛋白（MCH）和平均血红蛋白容积（MCV）升高（114 fL），表明存在大红细胞症。最后，在抗体检测结果显示抗平滑肌抗体、抗核抗体和抗胃顶细胞抗体阳性后，我们得出了自身免疫性病变的结论。患者在自身免疫性肝炎的情况下出现恶性贫血，这种病例极为罕见，现有文献中关于此类病例的记录也很少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.60

自引率

0.00%

发文量

320

审稿时长

8 weeks

期刊介绍： SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.