Chrysophanol: A promising natural compound in cancer therapy – Mechanistic insights and future perspectives

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY

Pharmacological research Pub Date : 2024-11-07 DOI:10.1016/j.phrs.2024.107502

Dehong Liu , Kun Zhu , Tao Guo , Yao Xiao , Meijing Wang , Yanxin Guan , Junjun Li , Degui Chang , Xujun Yu

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Abstract

Cancer continues to be a leading cause of death worldwide, highlighting the urgent need for the development of new therapeutic strategies. Chrysophanol, a naturally occurring anthraquinone compound, has demonstrated significant potential in cancer treatment due to its diverse biological activities. This review delves into the mechanisms through which chrysophanol exerts its anti-cancer effects, including the induction of cell cycle arrest, promotion of apoptosis, regulation of autophagy, and initiation of necrosis across various cancer cell lines. Additionally, the review discusses chrysophanol's impact on inhibiting cancer cell invasion and metastasis and its role in modulating chemotherapy sensitivity. Despite the promising therapeutic potential of chrysophanol, challenges such as poor water solubility, low bioavailability, and safety concerns remain. Comprehensive clinical trials are essential to validate its efficacy and safety. This review emphasizes chrysophanol as a promising candidate for cancer therapy and underscores the necessity for further research to fully harness its therapeutic potential.

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Chrysophanol：一种在癌症治疗中大有可为的天然化合物--机理认识与未来展望。

癌症仍然是导致全球死亡的主要原因，因此迫切需要开发新的治疗策略。蛹虫草酚是一种天然的蒽醌化合物，由于其具有多种生物活性，在癌症治疗方面已显示出巨大的潜力。本综述深入探讨了金丝桃醇发挥其抗癌作用的机制，包括诱导细胞周期停滞、促进细胞凋亡、调节自噬和引发各种癌细胞株的坏死。此外，综述还讨论了菊醇对抑制癌细胞侵袭和转移的影响，以及它在调节化疗敏感性方面的作用。尽管菊醇具有良好的治疗潜力，但仍存在水溶性差、生物利用率低和安全性问题等挑战。全面的临床试验对于验证其疗效和安全性至关重要。这篇综述强调了菊醇是一种很有希望的癌症治疗候选药物，并强调了进一步研究以充分利用其治疗潜力的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.