MicroRNA-146 family: Molecular insights into their role in regulation of signaling pathways in glioma progression

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-11-07 DOI:10.1016/j.prp.2024.155707

Sepideh Mirzaei , Fatemeh Ahangari , Fatemeh Faramarzi , Seyedeh Mahdieh Khoshnazar , Fateme Zare Khormizi , Mahboobeh Aghagolzadeh , Mohammadreza Rostami , Vahid Asghariazar , Mina Alimohammadi , Payman Rahimzadeh , Najma Farahani

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引用次数: 0

Abstract

Glioma is a highly lethal brain cancer in humans. Despite advancements in treatment, the prognosis for patients remains unfavorable. Epigenetic factors, along with their interactions and non-coding RNAs (ncRNAs), are crucial in glioma cells' development and aggressive characteristics. MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) that modulate the expression of various genes by binding to target mRNA molecules. They play a critical role in regulating essential biological mechanisms such as cell proliferation and differentiation, cell cycle, and apoptosis. MiR-146a/miR-146b is a significant and prevalent miRNA whose expression alterations are linked to various pathological changes in cancer cells, as well as the modulation of several cellular signaling pathways, including NF-κB, TGF-β, PI3K/Akt, and Notch-1. Scientists may identify novel targets in clinical settings by studying the complicated link between Mir-146a/mir-146b, drug resistance, molecular pathways, and pharmacological intervention in gliomas. Additionally, its interactions with other ncRNAs, such as circular RNA and long non-coding RNA, contribute to the pathogenesis of glioma. As well as miR-146 holds potential as both a diagnostic and therapeutic biomarker for patients with this condition. In the current review, we investigate the significance of miRNAs in the context of glioma, with a particular focus on the critical role of Mir-146a/mir-146b in glioma tumors. Additionally, we examined the clinical relevance of this miRNA, highlighting its potential implications for diagnosis and treatment.

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MicroRNA-146 家族：从分子角度揭示它们在胶质瘤进展过程中调控信号通路的作用。

胶质瘤是一种致死率极高的人类脑癌。尽管在治疗方面取得了进展，但患者的预后仍然不容乐观。表观遗传因子及其与非编码 RNA（ncRNA）的相互作用对胶质瘤细胞的发展和侵袭特性至关重要。微小RNA（miRNA）是一类小型非编码RNA（ncRNA），通过与目标mRNA分子结合来调节各种基因的表达。它们在调节细胞增殖和分化、细胞周期和细胞凋亡等重要生物机制方面发挥着关键作用。MiR-146a/miR-146b 是一种重要而普遍的 miRNA，其表达改变与癌细胞的各种病理变化以及 NF-κB、TGF-β、PI3K/Akt 和 Notch-1 等多种细胞信号通路的调节有关。科学家们可以通过研究 Mir-146a/mir-146b、胶质瘤的耐药性、分子通路和药物干预之间的复杂联系，确定新的临床靶点。此外，它与其他 ncRNA（如环状 RNA 和长非编码 RNA）之间的相互作用也有助于胶质瘤的发病机制。此外，miR-146 还有可能成为胶质瘤患者的诊断和治疗生物标志物。在本综述中，我们研究了 miRNA 在胶质瘤中的意义，尤其关注 Mir-146a/mir-146b 在胶质瘤肿瘤中的关键作用。此外，我们还研究了这种 miRNA 的临床意义，强调了它对诊断和治疗的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.