Comparison of tibial and femoral physeal diffusion tensor imaging in adolescents.

IF 2.1 3区医学 Q2 PEDIATRICS

Pediatric Radiology Pub Date : 2024-11-09 DOI:10.1007/s00247-024-06073-6

Laura Santos, Andressa Guariento, Sogol Moustoufi-Moab, Jie Nguyen, Rumana Tokaria, Jose Maria Raya, David Zurakowski, Sachin Jambawalikar, Diego Jaramillo

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引用次数: 0

Abstract

Background: Distal femoral diffusion tensor imaging (DTI) is a predictor of height gain but it is uncertain whether DTI can demonstrate differences in growth potential between the tibia and femur.

Objective: To explore the differences in structure and growth potential of the proximal tibia physeal-metaphyseal complex compared to those of the distal femur through DTI tractographic characterization and DTI metric comparison.

Materials and methods: Prospective cross-sectional study involved 108 healthy children (59 females) aged 8-14 years (females) and 10-16 years (males) around the growth spurt. We acquired knee DTI once at 3 T with b-values of 0 s/mm² and 600 s/mm². Tract parameters including number, length, volume, and fractional anisotropy were measured. Regression analysis with linear and negative binomial models, incorporating bone age-based quadratic fitting, characterized DTI parameter changes in relation to bone age and sex, as well as variations between physes. Femorotibial ratios were calculated based on paired DTI parameter absolute values during peak height gain. The study was approved by the institutional review board of two tertiary pediatric centers in compliance with the Health Insurance Portability and Accountability Act.

Results: Proximal tibial tracts were more numerous in the central physis, whereas distal femoral tracts predominated peripherally. Tract volume rose and fell during adolescence and peaked earlier in females (140-160 months vs. 160-180 months, P=0.02). At maximal height velocity (160 months), tibial tract volume (5.43 cc) was 37.4% of total knee tract volume (14.53 cc). Tibial fractional anisotropy decreased and then increased, both earlier than the femur.

Conclusion: Proximal tibial and distal femoral tract distributions differ. The tibia accounts for 37.4% of total knee tract volume during maximal height velocity. Tract volumes rise and fall, earlier in females. Tibiofemoral ratios of DTI metrics resemble known ratios of growth rates between tibia and femur.

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青少年胫骨和股骨骨盆弥散张量成像的比较。

背景：股骨远端弥散张量成像（DTI）是预测身高增长的一个指标，但DTI能否显示胫骨和股骨之间生长潜力的差异尚不确定：目的：通过 DTI 肌层特征描述和 DTI 指标比较，探讨胫骨近端骺板-骺板复合体与股骨远端骺板-骺板复合体在结构和生长潜力方面的差异：前瞻性横断面研究涉及 108 名健康儿童（59 名女性），年龄分别为 8-14 岁（女性）和 10-16 岁（男性），处于生长高峰期前后。我们在 3 T 下采集了一次膝关节 DTI，b 值分别为 0 s/mm2 和 600 s/mm2。测量了韧带参数，包括数量、长度、体积和各向异性分数。利用线性模型和负二项模型进行回归分析，并结合基于骨龄的二次拟合，确定了与骨龄和性别相关的 DTI 参数变化，以及不同体质之间的差异。根据身高增长峰值期间成对的 DTI 参数绝对值计算股胫骨比率。该研究获得了两家三级儿科中心机构审查委员会的批准，符合《健康保险可携性与责任法案》：结果：胫骨近端韧带在躯干中央较多，而股骨远端韧带则主要分布在外周。胫骨束的数量在青春期时增时减，女性达到峰值的时间更早（140-160个月对160-180个月，P=0.02）。在最高身高速度（160 个月）时，胫骨骨道体积（5.43 毫升）占膝关节总骨道体积（14.53 毫升）的 37.4%。胫骨骨折各向异性先减小后增大，均早于股骨：结论：胫骨近端和股骨远端骨路分布不同。结论：胫骨近端和股骨远端骨道分布不同，在最大高度速度时，胫骨占膝关节骨道总容量的37.4%。膝关节束体积的上升和下降在女性中更早。胫骨和股骨的DTI指标比率与已知的胫骨和股骨生长率比率相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Radiology 医学-核医学

CiteScore

4.40

自引率

17.40%

发文量

300

审稿时长

3-6 weeks

期刊介绍： Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.