Role of mitophagy in intervertebral disc degeneration: A narrative review.

IF 7.2 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage Pub Date : 2024-11-12 DOI:10.1016/j.joca.2024.09.013

Zuo-Long Wu, Yong Liu, Wei Song, Kai-Sheng Zhou, Yan Ling, Hai-Hong Zhang

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引用次数: 0

Abstract

Objective: The pivotal role of mitophagy in the initiation and progression of intervertebral disc (IVD) degeneration (IDD) has become increasingly apparent due to a growing body of research on its pathogenesis. This review summarizes the role of mitophagy in IDD and the therapeutic potential of targeting this process.

Design: This narrative review is divided into three parts: the regulatory mechanisms of mitophagy, the role of mitophagy in IDD, and the applications and prospects of mitophagy for the treatment of IDD.

Results: Mitophagy protects cells against harmful external stimuli and plays a crucial protective role by promoting extracellular matrix (ECM) production, inhibiting ECM degradation, and reducing apoptosis, senescence, and cartilage endplate calcification. However, excessive mitophagy is often detrimental to cells. Currently, the regulatory mechanisms governing appropriate and excessive mitophagy remain unclear.

Conclusions: Proper mitophagy effectively maintains IVD cell homeostasis and slows the progression of IDD. Conversely, excessive mitophagy may accelerate IDD development. Further research is needed to elucidate the regulatory mechanisms underlying appropriate and excessive mitophagy, which could provide new theoretical support for the application of mitophagy targeting to the treatment of IDD.

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有丝分裂在椎间盘退化中的作用：叙述性综述。

目的：随着对椎间盘（IVD）变性（IDD）发病机制研究的不断深入，有丝分裂在椎间盘（IVD）变性的发生和发展过程中的关键作用日益明显。本综述总结了有丝分裂在IDD中的作用以及针对这一过程的治疗潜力：本综述分为三个部分：有丝分裂的调控机制、有丝分裂在IDD中的作用以及有丝分裂在IDD治疗中的应用和前景：有丝分裂能保护细胞免受外界有害刺激，并通过促进细胞外基质（ECM）生成、抑制ECM降解、减少细胞凋亡、衰老和软骨终板钙化发挥重要的保护作用。然而，过度的有丝分裂往往对细胞有害。目前，适当和过度有丝分裂的调控机制仍不清楚：结论：适当的有丝分裂能有效维持 IVD 细胞的平衡并减缓 IDD 的进展。相反，过度的有丝分裂可能会加速 IDD 的发展。需要进一步研究阐明适当和过度有丝分裂的调控机制，这将为有丝分裂靶向治疗IDD提供新的理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.