Discovery of two new tirucallane-type triterpenes anomers from Toona ciliata.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-11-14 DOI:10.1080/14786419.2024.2429115

Aliya Tabassum, Harshad B Bhore, Jayanta Samanta, Anil Kumar Katare, Yogesh P Bharitkar

引用次数: 0

Abstract

Toona ciliata, a member of the Meliaceae family, is valued for its high-quality timber and medicinal potential in treating various ailments. In this study, two triterpene isomers were isolated and characterised as an inseparable mixture from its chloroform extract using chromatography and spectroscopic techniques. Despite rigorous/extensive attempts to separate these isomers, they co-crystallised in a consistent 67:33 ratio, as verified by X-ray crystallography. The structure was further confirmed by ESI-MS, HRMS,¹H NMR,¹³C NMR, DEPT 90, DEPT 135, COSY, NOESY, HSQC, and HMBC. Additionally, four more compounds were isolated successfully, out of that lutein and dyscusin C found for the first time from this plant.

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从 Toona ciliata 发现两种新的 tirucallane 型三萜异构体。

纤毛香椿（Toona ciliata）是木犀科植物，因其优质的木材和治疗各种疾病的药用潜力而备受重视。本研究利用色谱法和光谱技术，从其氯仿提取物中分离出两种三萜异构体，并对其进行了表征。尽管对这些异构体进行了严格/广泛的分离尝试，但经 X 射线晶体学验证，它们以 67:33 的一致比例共同结晶。通过 ESI-MS、HRMS、1H NMR、13C NMR、DEPT 90、DEPT 135、COSY、NOESY、HSQC 和 HMBC 进一步证实了其结构。此外，还成功分离出了另外四种化合物，其中叶黄素和黄豆苷 C 是首次从该植物中发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.