A new dammarane-type triterpenoid saponin from the leaves of sour jujube.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-11-13 DOI:10.1080/14786419.2024.2427814

Jin-Yan Tan, Pei Li, Si-Qi Yang, Jia-Ning Zhang, Yan-Gang Cheng

引用次数: 0

Abstract

A new dammarane-type triterpenoid saponin, suanzaoside A (1) along with one known analogue 3-O-[α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranosyl-]-30-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-3β,25,30-trihydroxy-16-one-20R,24R-epoxydammarane (2), were isolated from the leaves of sour jujube. The structure of these isolated compounds was elucidated by HRESIMS, 1D and 2D NMR spectroscopy, and literature comparison. In addition, the anti-inflammatory activities were further tested in LPS-induced RAW264.7 macrophage.

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从酸枣叶中提取的一种新的达玛烷型三萜类皂甙。

从酸枣叶中分离出一种新的达玛烷型三萜类皂甙--山楂苷 A（1）以及一种已知的类似物 3-O-[α-L-鼠李糖基-(1→2)-α-L-阿拉伯吡喃糖基-]-30-O-[β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基]-3β、25,30-三羟基-16-酮-20R,24R-环氧达玛烷 (2)。通过 HRESIMS、一维和二维核磁共振光谱以及文献对比，阐明了这些分离化合物的结构。此外，还在 LPS 诱导的 RAW264.7 巨噬细胞中进一步测试了这些化合物的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.