The Effects of Carbonate on Candida albicans Filamentation, Biofilm Formation, and Antifungal Resistance

IF 3.9 3区生物学 Q2 MICROBIOLOGY

MicrobiologyOpen Pub Date : 2024-11-13 DOI:10.1002/mbo3.70008

Trenton P. Miedema, Kayla E. Grooters, Ian A. Cleary

引用次数: 0

Abstract

Candida albicans, a member of the normal microbial population of healthy humans, is an opportunistic pathogen that can cause serious disease in immunocompromised patients. An important virulence factor of C. albicans is the formation of biofilms. These organized communities of cells are efficient at attaching to host cells and implanted medical devices. Carbonate has been studied as an agricultural antifungal agent, and here we demonstrate that carbonate can affect filamentation, biofilm formation, and antifungal drug resistance in C. albicans.

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碳酸盐对白色念珠菌丝状化、生物膜形成和抗真菌能力的影响

白色念珠菌是健康人体内正常微生物群的一员，但它是一种机会性病原体，可导致免疫力低下的病人患上严重疾病。白念珠菌的一个重要致病因素是形成生物膜。这些有组织的细胞群落能有效地附着在宿主细胞和植入的医疗设备上。碳酸盐作为一种农用抗真菌剂已被研究过，在这里我们证明碳酸盐能影响白僵菌的成丝、生物膜的形成和抗真菌药物的耐药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

MicrobiologyOpen MICROBIOLOGY-

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

20 weeks

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