Unveiling the antibacterial and antioxidant capabilities of Diospyros buxifolia leaf and stem extracts via GC-MS analysis.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-11-14 DOI:10.1080/14786419.2024.2425804

Praveen Kumar Basivi, Jayaletchumi Raman, Anitha Tippana, Vijay Kakani, Reetesh Kumar, Pasupuleti Visweswara Rao, Chang Woo Kim

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Abstract

Drug-resistant microorganisms pose a significant threat to public health as they can undermine the effectiveness of existing antibiotics and other medications. Additionally, the formation of free radicals, can contribute to various health problems. Diospyros buxifolia (D. buxifolia) belonging to Ebenaceae family is a large tropical evergreen tree utilised in traditional medicine to cure several health ailments. The present study was set out to separate bioactive speciation of aqueous and methanolic extracts of stem and leaves from D. buxifolia by using Gas Chromatography-Mass Spectrometry (GC-MS) followed by evaluation of its antimicrobial and antioxidant capabilities. GC-MS identified 14 different bioactive compounds, with four compounds common for both (leaf and stem) extracts. The methanolic extracts of leaf demonstrated significant antibacterial activity) while stem extracts exhibited notable antioxidant potential. Thus, D. buxifolia is proved source of natural antimicrobial and antioxidant agent, that could address the challenges posed by drug-resistant microorganisms and oxidative stress in global health.

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通过气相色谱-质谱分析揭示欧鼠李叶和茎提取物的抗菌和抗氧化能力。

耐药性微生物会破坏现有抗生素和其他药物的疗效，对公共健康构成重大威胁。此外，自由基的形成也会导致各种健康问题。枸杞子（Diospyros buxifolia）属于枸杞科，是一种大型热带常绿乔木，在传统医学中被用来治疗多种疾病。本研究利用气相色谱-质谱法（GC-MS）对欧鼠李的茎和叶的水提取物和甲醇提取物进行生物活性分类，然后对其抗菌和抗氧化能力进行评估。气相色谱-质谱法鉴定出 14 种不同的生物活性化合物，其中四种化合物在两种（叶和茎）提取物中都有。叶片的甲醇提取物具有明显的抗菌活性，而茎提取物则具有显著的抗氧化潜力。因此，D. buxifolia 被证明是天然抗菌剂和抗氧化剂的来源，可以应对全球健康中耐药微生物和氧化应激带来的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.