The role of the bilateral inferior frontal gyrus in non-suicidal self-injury (NSSI) among depressed adolescents: A functional near-infrared spectroscopy (fNIRS) study during verbal fluency tasks

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2024-11-05 DOI:10.1016/j.jpsychires.2024.11.005

Ziyang Peng , Xiaoli Liu , Fang Cheng , Yuanyuan Yin , Meng Chen , Jiyu Xie , Wenwu Zhang , Dongsheng Zhou

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引用次数: 0

Abstract

Background

The diagnosis and treatment of adolescents engaging in non-suicidal self-injury (NSSI) have been a clinical focus. We examined the hemodynamic changes in verbal fluency tasks (VFT) of adolescents with depression and NSSI, and its association with NSSI indexes.

Methods

Seventy-three adolescents with depression and NSSI and sixty-nine healthy controls (HCs) were employed. The VFT was performed by functional near-infrared spectroscopy (fNIRS). Independent-sample t-test, correlation analysis, and liner regression were measured.

Results

In the VFT, reduced hemodynamic changes were found in the NSSI group, including thirteen channels. Totally seven ROIs were defined according to which brain region these channels had the largest coverage and other channels that also belonged to it. They are the right inferior frontal gyrus (RIFG, t = −2.53, FDR corrected p = 0.02), right middle frontal gyrus (RMFG, t = −3.47, FDR corrected p = 0.002), right superior frontal gyrus (RSFG, t = −2.98, FDR corrected p = 0.005), left middle frontal gyrus (LMFG, t = −3.26, FDR corrected p = 0.002), left inferior frontal gyrus (LIFG, t = −2.80, FDR corrected p = 0.001), left precentral gyrus (LPrCG, t = −2.22, FDR corrected p = 0.03), and left supramarginal gyrus (LSMG, t = −2.20, FDR corrected p = 0.03). Negative correlations were found between the frequency of NSSI and the bilateral IFG (RIFG, r = −0.28, p = 0.01; LIFG, r = −0.26, p = 0.03). BDI and BAI have positive correlations with the frequency of NSSI (BDI: r = 0.42, FDR corrected p < 0.001; BAI: r = 0.41, FDR corrected p < 0.001), but results of liner regression showed that both of them do not affect the association between the frequency of NSSI and hemodynamic changes in bilateral IFG (RIFG, p = 0.01; LIFG, p = 0.04).

Conclusion

Adolescents with depression and NSSI have worse performance in the VFT, and lower activation in the bilateral IFG may represent a higher frequency of NSSI. These results help physicians enhance the understanding of adolescents with depression and NSSI.

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双侧额叶下回在抑郁青少年非自杀性自伤（NSSI）中的作用：语言流畅性任务中的功能性近红外光谱（fNIRS）研究。

背景：青少年非自杀性自伤（NSSI）的诊断和治疗一直是临床关注的焦点。我们研究了患有抑郁症和NSSI的青少年在言语流利性任务（VFT）中的血液动力学变化及其与NSSI指标的关联：方法：我们选取了 73 名患有抑郁症和 NSSI 的青少年以及 69 名健康对照组（HCs）。采用功能性近红外光谱（fNIRS）进行 VFT 检测。研究采用独立样本 t 检验、相关分析和衬垫回归法进行测量：结果：在 VFT 中发现，NSSI 组的血液动力学变化减少，包括 13 个通道。根据这些通道覆盖范围最大的脑区及其所属的其他通道，共定义了七个 ROI。它们分别是右额叶下回（RIFG，t = -2.53，FDR 校正后 p = 0.02）、右额叶中回（RMFG，t = -3.47，FDR 校正后 p = 0.002）、右额叶上回（RSFG，t = -2.98，FDR 校正后 p = 0.005）、左额叶中回（LMFG，t = -3.26，FDR 校正后 p = 0.005）、右额叶下回（RIFG，t = -2.53，FDR 校正后 p = 0.02）、右额叶中回（RMFG，t = -3.47，FDR 校正后 p = 0.002）、右额叶上回（RSFG，t = -2.98，FDR 校正后 p = 0.005）。26，FDR 校正 p = 0.002）、左额下回（LIFG，t = -2.80，FDR 校正 p = 0.001）、左中央前回（LPrCG，t = -2.22，FDR 校正 p = 0.03）和左边际上回（LSMG，t = -2.20，FDR 校正 p = 0.03）。NSSI频率与双侧IFG之间呈负相关（RIFG，r = -0.28，p = 0.01；LIFG，r = -0.26，p = 0.03）。BDI 和 BAI 与 NSSI 的频率呈正相关（BDI：r = 0.42，FDR 校正 p 结论：BDI 和 BAI 与 NSSI 的频率呈正相关：患有抑郁症和 NSSI 的青少年在 VFT 中的表现较差，而双侧 IFG 的激活较低可能代表 NSSI 的频率较高。这些结果有助于医生加深对患有抑郁症和 NSSI 的青少年的了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;