Assessment of response to PRRT including anatomical and molecular imaging as well as novel biomarkers.

IF 3.3 4区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Neuroendocrinology Pub Date : 2024-11-09 DOI:10.1111/jne.13461

Grace Kong, Geertje Noe, Cherie Chiang, Ken Herrmann, Thomas A Hope, Michael Michael

引用次数: 0

Abstract

Peptide receptor radionuclide therapy (PRRT) is an effective treatment for both oncological and hormone control and is a widely accepted standard of care treatment for patients with neuroendocrine neoplasms (NEN). Its use is anticipated to increase significantly, and this demands accurate tools and paradigms to assess treatment response post PRRT. This article outlines the current role and future developments of anatomical, molecular imaging and biomarkers for response assessment to PRRT, highlighting the challenges and provides perspectives for the need to focus on a multimodality, multidisciplinary and individualised approach for patients with this complex heterogeneous disease.

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对 PRRT 反应的评估，包括解剖和分子成像以及新型生物标志物。

肽受体放射性核素疗法（PRRT）是一种有效的肿瘤和激素控制治疗方法，也是神经内分泌肿瘤（NEN）患者广泛接受的标准治疗方法。预计该疗法的使用将大幅增加，这就需要精确的工具和范例来评估 PRRT 后的治疗反应。本文概述了用于 PRRT 反应评估的解剖学、分子影像学和生物标记物的当前作用和未来发展，强调了所面临的挑战，并从多个角度说明了对这种复杂的异质性疾病患者采用多模式、多学科和个体化方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroendocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.20%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.