CD93 aggravates cell proliferation, angiogenesis and immune escape in osteosarcoma through triggering the PI3K/AKT pathway.

IF 1.5 4区医学 Q3 ORTHOPEDICS

Journal of Orthopaedic Science Pub Date : 2024-11-13 DOI:10.1016/j.jos.2024.10.011

Yan Zhang, Yongheng Liu, Yulin Ma, Yao Xu, Guowen Wang, Xiuxin Han

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引用次数: 0

Abstract

Background: Osteosarcoma is the most familiar primary malignant tumor occurred in bone in young people and is featured by complicated genetic changes. CD93 has been affirmed to exhibit the facilitative roles in multiple cancers.

Methods: But, the detailed impacts and related regulatory pathway of CD93 in osteosarcoma progression maintain unclear.

Results: In this study, the elevated expression of CD93 was verified in osteosarcoma tissues from GEO database. Additionally, it was illustrated that CD93 existed the aggrandized mRNA and protein expressions in osteosarcoma cell lines. Moreover, suppression of CD93 restrained cell proliferation and angiogenesis in osteosarcoma. It was demonstrated that inhibition of CD93 retarded immune escape in osteosarcoma. Furthermore, CD93 triggered the PI3K/AKT pathway to aggravate the progression of osteosarcoma. At last, it was discovered that knockdown of CD93 attenuated tumor growth in vivo.

Conclusions: In conclusion, this study disclosed that CD93 aggravated cell proliferation, angiogenesis and immune escape in osteosarcoma through triggering the PI3K/AKT pathway. This work may supply useful opinions of CD93 on the cure of osteosarcoma.

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CD93 通过触发 PI3K/AKT 通路，加剧骨肉瘤的细胞增殖、血管生成和免疫逃逸。

背景：骨肉瘤是人们最熟悉的发生在年轻人骨骼中的原发性恶性肿瘤，具有复杂的遗传变化特征。CD93已被证实在多种癌症中发挥促进作用：但 CD93 在骨肉瘤进展过程中的具体影响及相关调控途径仍不清楚：结果：本研究从 GEO 数据库中验证了 CD93 在骨肉瘤组织中的高表达。此外，研究还表明 CD93 在骨肉瘤细胞系中的 mRNA 和蛋白表达量都有所升高。此外，抑制 CD93 可抑制骨肉瘤的细胞增殖和血管生成。研究表明，抑制 CD93 可延缓骨肉瘤的免疫逃逸。此外，CD93 还会触发 PI3K/AKT 通路，加剧骨肉瘤的恶化。最后，研究发现敲除 CD93 可减轻肿瘤在体内的生长：总之，本研究揭示了CD93通过触发PI3K/AKT通路加剧了骨肉瘤的细胞增殖、血管生成和免疫逃逸。这项工作可为CD93治疗骨肉瘤提供有益的意见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orthopaedic Science 医学-整形外科

CiteScore

3.00

自引率

0.00%

发文量

290

审稿时长

90 days

期刊介绍： The Journal of Orthopaedic Science is the official peer-reviewed journal of the Japanese Orthopaedic Association. The journal publishes the latest researches and topical debates in all fields of clinical and experimental orthopaedics, including musculoskeletal medicine, sports medicine, locomotive syndrome, trauma, paediatrics, oncology and biomaterials, as well as basic researches.