CD200-CD200R Pathway: A Regulator of Microglial Polarization in Postoperative Cognitive Dysfunction.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.2147/JIR.S489895

Jie Sun, Daoyun Lei

引用次数: 0

Abstract

Microglial polarization refers to the ability of microglia to exhibit different functional states under various conditions. As the resident immune cells of the brain, changes in the functional state of microglia play a crucial role in the progression of postoperative cognitive dysfunction. Recent studies have indicated that CD200-CD200R signaling is associated with microglial polarization. This review focuses on the latest advancements regarding whether CD200-CD200R signaling can regulate microglial polarization and thereby influence postoperative cognitive dysfunction.

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CD200-CD200R 通路：术后认知功能障碍中的小胶质细胞极化调节器

小胶质细胞极化指的是小胶质细胞在不同条件下表现出不同功能状态的能力。作为大脑的常驻免疫细胞，小胶质细胞功能状态的变化在术后认知功能障碍的进展中起着至关重要的作用。最近的研究表明，CD200-CD200R 信号与小胶质细胞极化有关。本综述将重点讨论 CD200-CD200R 信号是否能调节小胶质细胞极化从而影响术后认知功能障碍的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.