The Combined Effect of the Systemic Immune-Inflammation Index and Aortic Valve Calcification on Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.2147/JIR.S493735

Miaomiao Li, Mengchun Li, Zhenwei Wang, Yongbo Zhang

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Abstract

Background: The combined effect of systemic immune-inflammation index (SII) and aortic valve calcification (AVC) on the risk of major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD) remains unclear. This study aimed to investigate their combined association with MACE in CHD.

Methods: This retrospective cohort study included 846 CHD patients. SII was calculated as platelet count × neutrophil count / lymphocyte count, and AVC status was determined by echocardiography. Patients were divided into four groups based on median SII and AVC presence: Low SII + AVC (-), High SII + AVC (-), Low SII + AVC (+), and High SII + AVC (+). Cox regression, subgroup and sensitivity analyses assessed the association between SII + AVC and MACE.

Results: Multivariate Cox regression revealed that, compared to the Low SII + AVC (-), MACE risk increased 6.542-fold in the High SII + AVC (+) group and 1.605-fold in the High SII + AVC (-) group (P < 0.05). Subgroup analysis indicated that, compared to the Low SII + AVC (-), MACE risk was significantly elevated in the High SII + AVC (-) group for patients over 60, both genders, with hypertension, hyperlipidemia, or without diabetes (P < 0.05). In the Low SII + AVC (+) group, MACE risk was elevated only in males (P < 0.05). The High SII + AVC (+) group had increased MACE risk in all subgroups except those with diabetes (P < 0.05). After excluding patients with estimated glomerular filtration rate < 60 mL/min/1.73m², the high SII + AVC (+) group remained significantly associated with increased MACE risk (P = 0.001), as did the High SII + AVC (-) group (P = 0.031).

Conclusion: The combination of SII and AVC is significantly associated with MACE risk in patients with CHD.

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全身免疫炎症指数和主动脉瓣钙化对冠心病患者主要不良心血管事件的联合影响

背景：全身免疫炎症指数（SII）和主动脉瓣钙化（AVC）对冠心病（CHD）患者主要不良心血管事件（MACE）风险的联合影响仍不清楚。本研究旨在探讨这两种因素与冠心病 MACE 的关系：这项回顾性队列研究纳入了 846 名冠心病患者。SII以血小板计数×中性粒细胞计数/淋巴细胞计数计算，AVC状态通过超声心动图确定。根据 SII 和 AVC 存在的中位数，将患者分为四组：低 SII + AVC (-)、高 SII + AVC (-)、低 SII + AVC (+) 和高 SII + AVC (+)。Cox回归、亚组和敏感性分析评估了SII + AVC与MACE之间的关系：多变量 Cox 回归显示，与低 SII + AVC (-) 组相比，高 SII + AVC (+) 组的 MACE 风险增加了 6.542 倍，高 SII + AVC (-) 组的 MACE 风险增加了 1.605 倍（P < 0.05）。亚组分析表明，与低 SII + AVC (-) 组相比，高 SII + AVC (-) 组中 60 岁以上、有高血压、高脂血症或无糖尿病的男女患者的 MACE 风险显著升高（P < 0.05）。在低 SII + AVC (+) 组中，MACE 风险仅在男性中升高（P < 0.05）。高 SII + AVC (+) 组除糖尿病患者外，所有亚组的 MACE 风险均升高（P < 0.05）。在排除估计肾小球滤过率< 60 mL/min/1.73m² 的患者后，高SII + AVC (+) 组仍与MACE风险增加显著相关（P = 0.001），高SII + AVC (-) 组也是如此（P = 0.031）：结论：SII和AVC的组合与冠心病患者的MACE风险密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.