The association between oral diseases and neurodegenerative disorders.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-11-11 DOI:10.1177/13872877241289548

Lauriina Soiniemi, Eino Solje, Anna Liisa Suominen, Katja M Kanninen, Arja M Kullaa

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引用次数: 0

Abstract

Background: The association between cognitive neurodegenerative disease and oral diseases has been under great interest recently. Several studies have suggested a connection between periodontitis and Alzheimer's disease (AD) or other neurodegenerative disorders.

Objective: This study aimed to review the potential mechanisms between oral diseases and neurodegenerative diseases.

Methods: The study was executed as a literature review of English-language publications from 2018-2022. The databases used for the search were PubMed, Cochrane, Scopus, and Web of Science. The search phrases used were "neurodegenerative diseases" AND "oral health" and "neurodegenerative diseases" AND "oral diseases."

Results: The linkage between the two disease groups was observed in several distinct publications and several potential mechanisms were found. The link between periodontitis and AD proved to be the most significant. The effect was accentuated in elderly people where individuals possessed also other risk factors for neurodegenerative diseases and had generally worse oral health conditions.

Conclusions: Oral diseases may be risks for neurodegenerative changes along many different pathways. Good oral health should be acknowledged as a potential preventative or risk-reducing act against neurodegenerative diseases.

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口腔疾病与神经退行性疾病之间的关联。

背景：最近，认知神经退行性疾病与口腔疾病之间的关系受到了广泛关注。一些研究表明牙周炎与阿尔茨海默病（AD）或其他神经退行性疾病有关：本研究旨在回顾口腔疾病与神经退行性疾病之间的潜在机制：本研究对 2018-2022 年间的英文出版物进行了文献综述。用于检索的数据库有 PubMed、Cochrane、Scopus 和 Web of Science。检索词为 "神经退行性疾病 "和 "口腔健康 "以及 "神经退行性疾病 "和 "口腔疾病"：在几篇不同的出版物中观察到了这两类疾病之间的联系，并发现了几种潜在的机制。牙周炎与注意力缺失症之间的联系被证明是最重要的。这种影响在老年人中更为明显，因为这些人还具有其他神经退行性疾病的风险因素，而且口腔健康状况普遍较差：结论：口腔疾病可能是神经退行性病变的风险因素之一。良好的口腔健康应被视为预防或降低神经退行性疾病风险的潜在手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.