Efficacy of Infliximab in Experimental Tracheal Stenosis.

IF 1 4区医学 Q3 SURGERY

Journal of Craniofacial Surgery Pub Date : 2024-11-11 DOI:10.1097/SCS.0000000000010869

Abdulaziz Yalinkiliç, Fatma Ayaz Yalinkiliç, Burhan Beger, Mehmet Zeki Erdem, Hadice Uçar, Orhan Beger

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Abstract

Objective: This study aimed to investigate the efficacy of infliximab, a TNF-α inhibitor, on epithelial damage, inflammation, and fibrosis in experimental tracheal stenosis.

Methods: Rats were divided into 3 groups. In group 1 (the control group), no procedure was applied. Tracheotomy was opened in the other groups. The laryngotracheal mucosa of the rats was traumatized with a brush through the tracheostoma to create a stenosis model. After surgery, group 2 (the infliximab group) received 5 mg/kg infliximab intraperitoneally. In group 3 (the sham group) only 0.5 ml of saline (0.9% NaCl) was administered intraperitoneally. After 14 days, the rats were sacrificed. Tracheal rings were excised, and epithelial damage, inflammation, and fibrosis were evaluated histopathologically.

Results: Infliximab reduced the formation of epithelial damage (P=0.002), fibrosis (P=0.001), and inflammation (P=0.003) compared with the sham and control group.

Conclusion: This was the first investigation displaying the effects of infliximab on tracheal stenosis. The authors' experimental results may offer guidance for further studies. Their experience presents novel sights into optimizing outcomes in tracheal stenosis surgery, and so paves the way for further clinical examinations.

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英夫利西单抗对实验性气管狭窄的疗效

研究目的本研究旨在探讨 TNF-α 抑制剂英夫利昔单抗对实验性气管狭窄的上皮损伤、炎症和纤维化的疗效：大鼠分为 3 组。方法：将大鼠分为 3 组，第 1 组（对照组）不进行任何操作。其他各组均行气管切开术。用刷子通过气管造口创伤大鼠的喉气管粘膜，以建立气管狭窄模型。手术后，第 2 组（英夫利昔单抗组）腹腔注射 5 毫克/千克英夫利昔单抗。第3组（假组）仅腹腔注射0.5毫升生理盐水（0.9%氯化钠）。14 天后，大鼠被处死。切除气管环，对上皮损伤、炎症和纤维化进行组织病理学评估：结果：与假组和对照组相比，英夫利西单抗减少了上皮损伤（P=0.002）、纤维化（P=0.001）和炎症（P=0.003）的形成：这是首次研究英夫利西单抗对气管狭窄的影响。作者的实验结果可为进一步研究提供指导。他们的经验为优化气管狭窄手术的结果提供了新的视角，从而为进一步的临床研究铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Craniofacial Surgery 医学-外科

CiteScore

1.70

自引率

11.10%

发文量

968

审稿时长

1.5 months

期刊介绍： The Journal of Craniofacial Surgery serves as a forum of communication for all those involved in craniofacial surgery, maxillofacial surgery and pediatric plastic surgery. Coverage ranges from practical aspects of craniofacial surgery to the basic science that underlies surgical practice. The journal publishes original articles, scientific reviews, editorials and invited commentary, abstracts and selected articles from international journals, and occasional international bibliographies in craniofacial surgery.