Replacement of the main bile duct by bioprosthesis in an experimental porcine model (24-month results)

IF 2.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Hpb Pub Date : 2025-01-01 DOI:10.1016/j.hpb.2024.10.009

Eduardo E. Montalvo-Javé , Benjamín León-Mancilla , Mariana Espejel-Deloiza , Jonathan Chernizky , Alan Valderrama-Treviño , María C. Piña-Barba , César Montalvo-Arenas , Carlos Gutiérrez-Banda , Rita Dorantes-Heredia , Natalia Nuño-Lámbarri

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引用次数: 0

Abstract

Background

Cholecystectomy for conditions like iatrogenic injury during cholecystectomy can lead to complications such as bile duct injuries, necessitating alternative options like bioprosthesis.

Methods

This study evaluated a bioprosthesis’s efficacy in maintaining bile duct continuity over 24 months in 16 male pigs.

Results

The bioprosthesis was implanted in the common bile duct of three-month-old animals, with follow-ups at 1, 6, 12, 18, and 24 months. Liver function remained stable, and biliary permeability was assessed through various imaging techniques. Despite mild stenosis, biliary flow was unimpeded. Histological analysis confirmed biliary epithelium presence in the regenerated area.

Conclusion

The bioprosthesis acted as a scaffold for tissue regeneration without compromising biliary function. Remnants of the bioprosthesis were observed but did not affect biliary excretion in the 24-month porcine model. This study highlights the bioprosthesis’s potential in bile duct reconstruction, offering a safe and effective option for maintaining biliary continuity.

查看原文本刊更多论文

在实验猪模型中用生物假体置换主胆管（24 个月的结果）。

背景：胆囊切除术中的先天性损伤等情况会导致胆管损伤等并发症，因此需要生物假体等替代方案：本研究评估了生物假体在16头雄性猪体内维持胆管连续性24个月的效果：结果：将生物假体植入三个月大的动物的胆总管，并在 1、6、12、18 和 24 个月时进行随访。肝功能保持稳定，胆道通透性通过各种成像技术进行了评估。尽管胆管轻度狭窄，但胆汁流动畅通无阻。组织学分析证实，再生区域存在胆道上皮：结论：生物假体是组织再生的支架，不会影响胆道功能。在为期 24 个月的猪模型中，观察到了生物假体的残留物，但不会影响胆汁排泄。这项研究强调了生物假体在胆管重建中的潜力，为保持胆道连续性提供了一种安全有效的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hpb GASTROENTEROLOGY & HEPATOLOGY-SURGERY

CiteScore

5.60

自引率

3.40%

发文量

244

审稿时长

57 days

期刊介绍： HPB is an international forum for clinical, scientific and educational communication. Twelve issues a year bring the reader leading articles, expert reviews, original articles, images, editorials, and reader correspondence encompassing all aspects of benign and malignant hepatobiliary disease and its management. HPB features relevant aspects of clinical and translational research and practice. Specific areas of interest include HPB diseases encountered globally by clinical practitioners in this specialist field of gastrointestinal surgery. The journal addresses the challenges faced in the management of cancer involving the liver, biliary system and pancreas. While surgical oncology represents a large part of HPB practice, submission of manuscripts relating to liver and pancreas transplantation, the treatment of benign conditions such as acute and chronic pancreatitis, and those relating to hepatobiliary infection and inflammation are also welcomed. There will be a focus on developing a multidisciplinary approach to diagnosis and treatment with endoscopic and laparoscopic approaches, radiological interventions and surgical techniques being strongly represented. HPB welcomes submission of manuscripts in all these areas and in scientific focused research that has clear clinical relevance to HPB surgical practice. HPB aims to help its readers - surgeons, physicians, radiologists and basic scientists - to develop their knowledge and practice. HPB will be of interest to specialists involved in the management of hepatobiliary and pancreatic disease however will also inform those working in related fields. Abstracted and Indexed in: MEDLINE® EMBASE PubMed Science Citation Index Expanded Academic Search (EBSCO) HPB is owned by the International Hepato-Pancreato-Biliary Association (IHPBA) and is also the official Journal of the American Hepato-Pancreato-Biliary Association (AHPBA), the Asian-Pacific Hepato Pancreatic Biliary Association (A-PHPBA) and the European-African Hepato-Pancreatic Biliary Association (E-AHPBA).