Elevated hematologic ratios are correlated with acne severity: a national, retrospective cohort study.

IF 3.1 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Frontiers in Medicine Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.3389/fmed.2024.1475117

Vered Wiesel, Sarah Weissmann, Bracha Cohen, Inbal Golan-Tripto, Amir Horev

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引用次数: 0

Abstract

Background: Prior studies demonstrated conflicting results regarding hematologic ratios in acne patients. We sought to further characterize hematologic ratios in acne patients, according to demographics and acne severity.

Methods: National, retrospective cohort study of 122,822 patients using medical records from 2005 to 2024 of patients insured with the largest public healthcare organization in Israel, Clalit Health Maintenance Organization.

Results: Moderate-severe acne patients had higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) than mild acne patients at diagnosis and 12-18 months before diagnosis. A multivariable regression confirmed the significance of the correlation of increased NLR and PLR with acne severity. Adults and females had higher NLR and PLR than children and males, respectively, at diagnosis, and 12-18 months before diagnosis.

Conclusion: Acne severity was significantly associated with elevated NLR and PLR. NLR and PLR may also serve as indicators of upcoming acne severity, as they were elevated 12-18 months before diagnosis. These biomarkers may contribute to the diagnosis, management, and follow-up of patients with acne.

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血液学比率升高与痤疮严重程度相关：一项全国性回顾性队列研究。

背景：先前的研究显示，痤疮患者的血液学比率结果相互矛盾。我们试图根据人口统计学和痤疮严重程度，进一步确定痤疮患者血液学比率的特征：采用以色列最大的公共医疗机构--Clalit健康维护组织--2005年至2024年的医疗记录，对122,822名患者进行全国性回顾性队列研究：与轻度痤疮患者相比，中度重度痤疮患者在诊断时和诊断前12-18个月的中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）较高。多变量回归证实了 NLR 和 PLR 的升高与痤疮严重程度的显著相关性。在诊断时和诊断前12-18个月，成人和女性的NLR和PLR分别高于儿童和男性：结论：痤疮的严重程度与 NLR 和 PLR 的升高密切相关。结论：痤疮严重程度与 NLR 和 PLR 升高有明显关系。NLR 和 PLR 也可作为痤疮严重程度的指标，因为它们在诊断前 12-18 个月就已升高。这些生物标志物可能有助于痤疮患者的诊断、管理和随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Medicine Medicine-General Medicine

CiteScore

5.10

自引率

5.10%

发文量

3710

审稿时长

12 weeks

期刊介绍： Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world