Exploring the role of fatty acid esters of hydroxy fatty acids in metabolic dysfunction-associated steatotic liver disease in morbidly obese women.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2024-11-11 DOI:10.1016/j.dld.2024.09.026

Laia Bertran, Elena Cristina Rusu, Carmen Aguilar, Teresa Auguet, Cristóbal Richart

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引用次数: 0

Abstract

Background: Fatty acid esters of hydroxy fatty acids (FAHFAs) present potential beneficial effects that could offer valuable insights into metabolic and inflammatory diseases. However, few FAHFAs have been studied, and their role is unclear.

Aims: To assess FAHFA levels in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) associated with morbid obesity (MO) to explore the potential significance of FAHFAs under these conditions.

Methods: Using ultra-precise liquid chromatography, FAHFA serum levels were measured in 219 women, including 53 with normal weight (NW) and 166 with MO. The MO group was classified by histological diagnosis into 35 normal liver (NL), 38 simple steatosis (SS) and 93 metabolic dysfunction-associated steatohepatitis (MASH) groups.

Results: Thirty-two FAHFA isoforms from 11 families were identified. Most FAHFAs presented low levels in MO, but tLAHOAs, LAHOA-1 and OAHOA-1 increased. In MASLD, elevated tLAHPO, LAHPO-2, PAHLA-3 and PAHLA-4 levels were observed. In MASH, increased POHLA-1, tLAHPOs, LAHPO-2 and LAHLA-3 and decreased PAHSA-1, tOAHOAs, OAHSA-2 and OAHSA-3 levels were reported.

Conclusion: This study reveals novel insights into FAHFAs in a cohort of women with MO with MASLD. In MASLD, we reported only increased levels of certain FAHFAs. In MASH, we found a different profile that could be characteristic.

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探索羟基脂肪酸酯在病态肥胖女性代谢功能障碍相关脂肪性肝病中的作用。

背景：羟基脂肪酸的脂肪酸酯（FAHFAs）具有潜在的有益作用，可为代谢性和炎症性疾病提供有价值的见解。目的：评估与病态肥胖（MO）相关的代谢功能障碍相关性脂肪性肝病（MASLD）患者体内的脂肪酸酯水平，探讨脂肪酸酯在这些情况下的潜在意义：采用超精密液相色谱法测量了219名女性的FAHFA血清水平，其中包括53名正常体重（NW）女性和166名病态肥胖（MO）女性。MO组根据组织学诊断分为35个正常肝脏组（NL）、38个单纯脂肪变性组（SS）和93个代谢功能障碍相关性脂肪性肝炎组（MASH）：结果：发现了来自 11 个家族的 32 种 FAHFA 同工型。在 MO 中，大多数 FAHFAs 的水平较低，但 tLAHOAs、LAHOA-1 和 OAHOA-1 的水平升高。在 MASLD 中，观察到 tLAHPO、LAHPO-2、PAHLA-3 和 PAHLA-4 水平升高。在 MASH 中，POHLA-1、tLAHPOs、LAHPO-2 和 LAHLA-3 水平升高，PAHSA-1、tOAHOAs、OAHSA-2 和 OAHSA-3 水平降低：本研究揭示了在一组患有 MO 和 MASLD 的妇女中 FAHFAs 的新见解。在 MASLD 中，我们仅报告了某些 FAHFAs 水平的升高。在 MASH 中，我们发现了不同的特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.