Different Pathways of Skin Aging: Objective Instrumental Evaluation.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Noah Musolff, Carmen Cantisani, Stefania Guida, Simone Michelini, Madeline Tchack, Babar Rao, Giovanni Pellacani
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Abstract

Background/Objectives: Hypertrophic and atrophic skin aging represent two distinct phenotypes: hypertrophic aging is marked by deep wrinkles and a leathery texture, whereas atrophic aging is characterized by overall skin thinning, increased vascularity, and a higher risk of non-melanoma skin cancers. This study aims to elucidate the characteristics and differences between hypertrophic and atrophic facial aging subtypes using two non-invasive imaging devices: VISIA® and dynamic optical coherence tomography (D-OCT). Methods: We retrospectively evaluated patients who had presented to the outpatient dermatological clinic at Policlinico Umberto I hospital in Rome, Italy for a non-invasive facial imaging check-up. We included 40 patients aged 60-75 who were imaged with VISIA® and dynamic optical coherence tomography (D-OCT). Based on the number of UV spots and amount of red found on VISIA®, subjects were grouped into four subgroups (PIGM, RED, CONTROL, PIGM + RED), and trends among them were analyzed. Results: We found a strong correlation between VISIA® red area scores and D-OCT vascular density at 300 µm depth, confirming VISIA®'s effectiveness for assessing facial vascularity. Wrinkle count was highest in areas with UV spots, particularly in the PIGM and PIGM + RED groups. Conversely, low attenuation coefficients and dermal density were observed in regions with low UV spots but high red areas. Intermediate subgroups (CONTROL and PIGM + RED) displayed varying parameters. Conclusions: Non-invasive imaging devices are effective in evaluating facial aging and distinguishing between aging subtypes. This study identified two intermediate aging types in addition to the hypertrophic and atrophic subtypes.

皮肤老化的不同途径:客观仪器评估
背景/目标:肥厚性和萎缩性皮肤老化代表了两种不同的表型:肥厚性老化的特点是皱纹深、质地如皮革,而萎缩性老化的特点是皮肤整体变薄、血管增多以及罹患非黑素瘤皮肤癌的风险较高。本研究旨在利用两种无创成像设备,阐明肥厚型和萎缩型面部衰老亚型的特征和差异:VISIA® 和动态光学相干断层扫描 (D-OCT)。方法:我们对前往意大利罗马翁贝托一世医院(Policlinico Umberto I hospital)皮肤科门诊进行无创面部成像检查的患者进行了回顾性评估。我们对 40 名 60-75 岁的患者进行了 VISIA® 和动态光学相干断层扫描(D-OCT)成像。根据在 VISIA® 上发现的紫外线斑点数量和红色数量,受试者被分为四个亚组(PIGM、RED、CONTROL、PIGM + RED),并对它们之间的趋势进行了分析。结果:我们发现 VISIA® 红色区域得分与 300 微米深度的 D-OCT 血管密度之间存在很强的相关性,这证实了 VISIA® 在评估面部血管方面的有效性。有紫外线斑点的区域皱纹数最多,尤其是在 PIGM 组和 PIGM + RED 组。相反,在紫外线斑点较少但红色区域较多的区域,衰减系数和真皮密度较低。中间亚组(CONTROL 和 PIGM + RED)显示出不同的参数。结论无创成像设备可有效评估面部衰老并区分衰老亚型。除肥厚和萎缩亚型外,本研究还发现了两种中间老化类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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