First-in-Human: Simultaneous Hyperpolarized 1-13C-Pyruvate Magnetic Resonance Spectroscopy and 18F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2024-11-12 DOI:10.1097/RLU.0000000000005534

Mathias Loft, Andreas Clemmensen, Emil Nørgaard Christensen, Charlotte Lund Denholt, Helle Hjorth Johannesen, Nic Gillings, Esben Andreas Carlsen, Malene Martini Clausen, Martin Hutchings, Thomas Lund Andersen, Jan Henrik Ardenkjær-Larsen, Andreas Kjaer

引用次数: 0

Abstract

Abstract: Hyperpolarized 1-13C-pyruvate magnetic resonance spectroscopy (MRS) and MRS imaging (MRSI) offer noninvasive and real-time direct assessment of the altered metabolism of cancer cells known as the Warburg effect-a key hallmark of cancer. When combined with simultaneously acquired 18F-FDG PET in a PET/MR scanner, coined hyperPET by us, this dual-modality may unveil cancer-type specific glucose metabolic phenotypes with potential implications for patient prognostication, treatment-response assessment, and prediction. We here present the first human data of simultaneously acquired hyperpolarized MRS/MRSI and PET performed in a PET/MR scanner-and the first human hyperpolarized MRS/MRSI data from a patient with lymphoma.

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首次应用于人体：对一名淋巴瘤患者同时进行超极化 1-13C-Pyruvate 磁共振波谱和 18F-FDG PET（hyperPET）成像。

摘要：超极化 1-13C 丙酮酸磁共振波谱（MRS）和 MRS 成像（MRSI）可无创、实时地直接评估被称为沃伯格效应的癌细胞代谢改变--这是癌症的关键标志。当在 PET/MR 扫描仪中结合同时获得的 18F-FDG PET（我们称之为 hyperPET）时，这种双模式可揭示癌症类型特定的葡萄糖代谢表型，对患者预后、治疗反应评估和预测具有潜在的影响。我们在此展示了在 PET/MR 扫描仪中同时获取超极化 MRS/MRSI 和 PET 的首个人类数据，以及来自淋巴瘤患者的首个人类超极化 MRS/MRSI 数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.