Genomic diversity and transmission patterns of Yersinia pestis in Inner Mongolia Autonomous Region, China.

IF 5.2 1区生物学 Q1 BIOLOGY

Communications Biology Pub Date : 2024-11-09 DOI:10.1038/s42003-024-07190-6

Xiujuan Zuo, Fang Liu, Yanhong Hu, Xuezhi Huang, Yan Guo, Mengnan Cui, Hang Fan, Xianglilan Zhang, Zhenghua Wu, Wenrui Wang, Ruifu Yang, Yarong Wu, Jianyun Li, Yujun Cui

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引用次数: 0

Abstract

According to WHO, plague, caused by Yersinia pestis, has resurged since 2000. Inner Mongolia, harboring a quarter of China's plague foci, has accounted for 80% of national plague cases in the past five years. Despite its pivotal role in Chinese plague epidemiology, the genetic diversity and transmission dynamics of Y. pestis in this region remain under-investigated. Our analysis of 585 Y. pestis strains from Inner Mongolia (1948-2021) revealed three primary lineages, with 2.MED3 being predominant. We further delineated seven sub-phylogroups in 2.MED3, with 2.MED3.1.2 and 2.MED3.1.4 showing recent dominance. These two subgroups reveal dual transmission patterns: localized short-distance spread and long-distance dispersals over 300 km. Xilingol League is highlighted as a key source and reservoir for Y. pestis, predominantly spreading from central-eastern to southwestern Inner Mongolia, including occasional reverse transmissions. These findings enhance understanding of Y. pestis diversity and transmission in Inner Mongolia, aiding in enhanced surveillance and control measures.

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中国内蒙古自治区鼠疫耶尔森菌的基因组多样性和传播模式。

据世界卫生组织称，由鼠疫耶尔森氏菌引起的鼠疫自 2000 年以来再次爆发。内蒙古占中国鼠疫疫点的四分之一，在过去五年中，内蒙古鼠疫病例占全国鼠疫病例的80%。尽管内蒙古在中国鼠疫流行病学中占有举足轻重的地位，但对该地区鼠疫 Y. pestis 的遗传多样性和传播动态的研究仍然不足。我们对来自内蒙古（1948-2021年）的585株鼠疫耶氏菌进行了分析，发现了三个主要的品系，其中以2.MED3为主。我们进一步划分了2.MED3中的七个亚系统群，其中2.MED3.1.2和2.MED3.1.4在近期占主导地位。这两个亚群显示了双重传播模式：局部短距离传播和 300 公里以上的长距离传播。锡林郭勒盟是鼠疫 Y. 的主要来源和贮藏地，主要从内蒙古中东部向西南部传播，包括偶尔的反向传播。这些发现加深了人们对内蒙古鼠疫耶氏菌多样性和传播的了解，有助于加强监测和控制措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Communications Biology Medicine-Medicine (miscellaneous)

CiteScore

8.60

自引率

1.70%

发文量

1233

审稿时长

13 weeks

期刊介绍： Communications Biology is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the biological sciences. Research papers published by the journal represent significant advances bringing new biological insight to a specialized area of research.