The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers

IF 3.5 4区医学 Q2 CHEMISTRY, MEDICINAL

Drug Development Research Pub Date : 2024-11-11 DOI:10.1002/ddr.70014

Ruixi Xie, Ying Luo, Bowen Bao, Xinshu Wu, Jia Guo, Jin Wang, Xiujuan Qu, Xiaofang Che, Chunlei Zheng

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引用次数: 0

Abstract

Gastrointestinal cancer has emerged as a significant global health concern due to its high incidence and mortality, limited effectiveness of early detection, suboptimal treatment outcomes, and poor prognosis. Metabolic reprogramming is a prominent feature of cancer, and fatty acid metabolism assumes a pivotal role in bridging glucose metabolism and lipid metabolism. Fatty acids play important roles in cellular structural composition, energy supply, signal transduction, and other lipid-related processes. Changes in the levels of fatty acid metabolite may indicate the malignant transformation of gastrointestinal cells, which have an impact on the prognosis of patients and can be used as a marker to monitor the efficacy of anticancer therapy. Therefore, targeting key enzymes involved in fatty acid metabolism, either as monotherapy or in combination with other agents, is a promising strategy for anticancer treatment. This article reviews the potential mechanisms of fatty acid metabolism disorders in the occurrence and development of gastrointestinal tumors, and summarizes the related potential biomarkers and anticancer strategies.

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脂肪酸代谢的作用、相关潜在生物标记物以及胃肠道癌症的靶向治疗策略。

胃肠癌发病率高、死亡率高、早期检测效果有限、治疗效果不理想以及预后不良，已成为全球关注的重大健康问题。代谢重编程是癌症的一个显著特征，而脂肪酸代谢在葡萄糖代谢和脂质代谢之间起着关键作用。脂肪酸在细胞结构组成、能量供应、信号转导和其他脂质相关过程中发挥着重要作用。脂肪酸代谢物水平的变化可能预示着胃肠道细胞的恶性转化，对患者的预后有影响，并可作为监测抗癌疗法疗效的标志物。因此，靶向参与脂肪酸代谢的关键酶，无论是作为单一疗法还是与其他药物联合使用，都是一种很有前景的抗癌治疗策略。本文综述了脂肪酸代谢紊乱在胃肠道肿瘤发生和发展中的潜在机制，并总结了相关的潜在生物标记物和抗癌策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Development Research 医学-药学

CiteScore

6.40

自引率

2.60%

发文量

104

审稿时长

6-12 weeks

期刊介绍： Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.